Literature DB >> 20589129

Youth of West Cameroon are at high risk of developing IDD due to low dietary iodine and high dietary thiocyanate.

Ibrahim Taga1, Valere Aime Soh Oumbe, Robert Johns, Mohsin Abbas Zaidi, Ngogang Jeanne Yonkeu, Illimar Altosaar.   

Abstract

OBJECTIVES: Hypothyroidism in utero leading to mental retardation is highly prevalent and recurrent in developing countries where iodine deficiency and thiocyanate overload are combined. So, to explore and identify human population's risks for developing iodine deficiency disorders and their endemicity in Western Cameroon, with the aim to prevent this deficiency and to fight again it, urinary iodine and thiocyanate levels were determined.
METHODS: The district of Bamougoum in Western Cameroon was selected for closer study due to its geographic location predisposing for iodine deficiency disorders (IDD). A comprehensive sampling strategy included 24-h urine samples collected over three days from 120 school-aged children. Urinary iodine and thiocyanate levels were measured by colorimetric methods.
RESULTS: Twenty one percent of boys between the ages 3 and 19 were classified as iodine deficient. The prevalence of thiocyanate overload in the same population was found to be 20%.
CONCLUSION: Presence of endemic iodine deficiency and excessive thiocyanate in the population indicates that the region is at risk of iodine deficiency disorder. A multifactorial approach that includes improvement of diet, increasing iodine and minimizing goitrogen substances intake, soil and crop improvement and an iodine supplementation program may help alleviate IDD in the affected area studied.

Entities:  

Keywords:  Cameroon; IDD; IDD in West Cameroon; food; human; iodine; iodine deficiency disorder; thiocyanate; urine

Mesh:

Substances:

Year:  2008        PMID: 20589129      PMCID: PMC2887014     

Source DB:  PubMed          Journal:  Afr Health Sci        ISSN: 1680-6905            Impact factor:   0.927


  32 in total

1.  Increased risk of iodine deficiency with vegetarian nutrition.

Authors:  T Remer; A Neubert; F Manz
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Review 2.  Goitre and environmental iodine deficiency in the UK--Derbyshire: a review.

Authors:  Sohel Q Saikat; Joy E Carter; Aradhana Mehra; Barry Smith; Alex Stewart
Journal:  Environ Geochem Health       Date:  2004-12       Impact factor: 4.609

3.  Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter.

Authors:  Massimo Tonacchera; Aldo Pinchera; Antonio Dimida; Eleonora Ferrarini; Patrizia Agretti; Paolo Vitti; Ferruccio Santini; Kenny Crump; John Gibbs
Journal:  Thyroid       Date:  2004-12       Impact factor: 6.568

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Authors:  G F Maberly; F L Trowbridge; R Yip; K M Sullivan; C E West
Journal:  Annu Rev Public Health       Date:  1994       Impact factor: 21.981

5.  Geochemistry of trace elements in paddy (rice) soils of Sri Lanka--implications for iodine deficiency disorders (IDD).

Authors:  Rohana Chandrajith; Chandra B Dissanayake; Heinz J Tobschall
Journal:  Environ Geochem Health       Date:  2005-02       Impact factor: 4.609

Review 6.  Role of goitrogens in iodine deficiency disorders & brain development.

Authors:  P S Rao; R Lakshmy
Journal:  Indian J Med Res       Date:  1995-11       Impact factor: 2.375

7.  Engineering cyanogen synthesis and turnover in cassava (Manihot esculenta).

Authors:  Dimuth Siritunga; Richard Sayre
Journal:  Plant Mol Biol       Date:  2004-11       Impact factor: 4.076

8.  Endemic goitre in the absence of iodine deficiency in schoolchildren of the Northern Cape Province of South Africa.

Authors:  P L Jooste; M J Weight; J A Kriek; A J Louw
Journal:  Eur J Clin Nutr       Date:  1999-01       Impact factor: 4.016

9.  Iodine deficiency, other trace elements, and goitrogenic factors in the etiopathogeny of iodine deficiency disorders (IDD).

Authors:  C H Thilly; J B Vanderpas; N Bebe; K Ntambue; B Contempre; B Swennen; R Moreno-Reyes; P Bourdoux; F Delange
Journal:  Biol Trace Elem Res       Date:  1992 Jan-Mar       Impact factor: 3.738

Review 10.  Seven deadly sins in confronting endemic iodine deficiency, and how to avoid them.

Authors:  J T Dunn
Journal:  J Clin Endocrinol Metab       Date:  1996-04       Impact factor: 5.958

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2.  Prevalence and Pattern of Thyroid Disorders among Patients Attending University of Nigeria Teaching Hospital, Enugu, Southeastern Nigeria.

Authors:  Edwin Nkemjika Okafor; Martin C Ugonabo; Ekene E Chukwukelu; Innocent N Okonkwo; Enyuche Ezigbo; Obiageli Odurukwe
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  2 in total

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