OBJECTIVES: To determine normal hematologic and selected blood chemistry values among healthy, full-term, non-HIV-exposed infants in Uganda and Malawi, and to determine the proportion of healthy babies with an apparent laboratory toxicity based on Division of AIDS toxicity tables. DESIGN: This was a cross-sectional laboratory study of infants from birth to 6 months of age. METHODS: Blood samples were collected from a total of 561 infants and analyzed according to age categories similar to those in the 2004 Division of AIDS toxicity tables. Select chemistry and hematology parameters were determined and values compared with those in the toxicity tables. RESULTS: In the first 56 days of life, there were few graded toxicities except for neutropenia in 2 of 10 (20%) Ugandan and 13 of 45 (29%) Malawian infants at birth. After 7 days, about 20% of the infants in Uganda and Malawi would have been classified as having a neutropenia whereas 47% and 53% of those more than 2 months of age in Uganda and Malawi respectively, would have been reported as having an abnormal hemoglobin. Chemistry findings were not different from US norms. CONCLUSIONS: These findings underscore the importance of establishing relevant local laboratory norms for infants.
OBJECTIVES: To determine normal hematologic and selected blood chemistry values among healthy, full-term, non-HIV-exposed infants in Uganda and Malawi, and to determine the proportion of healthy babies with an apparent laboratory toxicity based on Division of AIDS toxicity tables. DESIGN: This was a cross-sectional laboratory study of infants from birth to 6 months of age. METHODS: Blood samples were collected from a total of 561 infants and analyzed according to age categories similar to those in the 2004 Division of AIDS toxicity tables. Select chemistry and hematology parameters were determined and values compared with those in the toxicity tables. RESULTS: In the first 56 days of life, there were few graded toxicities except for neutropenia in 2 of 10 (20%) Ugandan and 13 of 45 (29%) Malawian infants at birth. After 7 days, about 20% of the infants in Uganda and Malawi would have been classified as having a neutropenia whereas 47% and 53% of those more than 2 months of age in Uganda and Malawi respectively, would have been reported as having an abnormal hemoglobin. Chemistry findings were not different from US norms. CONCLUSIONS: These findings underscore the importance of establishing relevant local laboratory norms for infants.
Authors: Eric S Lugada; Jonathan Mermin; Frank Kaharuza; Elling Ulvestad; Willy Were; Nina Langeland; Birgitta Asjo; Sam Malamba; Robert Downing Journal: Clin Diagn Lab Immunol Date: 2004-01
Authors: Llorenç Quintó; John J Aponte; Jahit Sacarlal; Mateu Espasa; Pedro Aide; Inacio Mandomando; Caterina Guinovart; Eusebio Macete; Margarita M Navia; Ricardo Thompson; Clara Menéndez; Pedro L Alonso Journal: Trop Med Int Health Date: 2006-11 Impact factor: 2.622
Authors: Taha E Taha; Newton Kumwenda; Amanda Gibbons; Donald Hoover; Valentino Lema; Susan Fiscus; Joshua Mukiibi; George Liomba; Robin Broadhead Journal: AIDS Date: 2002-04-12 Impact factor: 4.177
Authors: J M Mukiibi; L A Mtimavalye; R Broadhead; E Mzula; W E Dzinyemba; R Merrick; C O Khoromana; G W Ching'ani Journal: East Afr Med J Date: 1995-01
Authors: Victoria B Chou; Saad B Omer; Hamidah Hussain; Christine Mugasha; Maria Musisi; Francis Mmiro; Philippa Musoke; J Brooks Jackson; Laura A Guay Journal: J Acquir Immune Defic Syndr Date: 2007-12-01 Impact factor: 3.731
Authors: Newton I Kumwenda; Tiwonge Khonje; Linda Mipando; Kondwani Nkanaunena; Pauline Katundu; Irene Lubega; Ali Elbireer; Steve Bolton; Danstan Bagenda; Michael Mubiru; Mary Glenn Fowler; Taha E Taha Journal: Paediatr Int Child Health Date: 2012 Impact factor: 1.990
Authors: Michele Tameris; Helen McShane; J Bruce McClain; Bernard Landry; Stephen Lockhart; Angelique K K Luabeya; Hennie Geldenhuys; Jacqui Shea; Gregory Hussey; Linda van der Merwe; Marwou de Kock; Thomas Scriba; Robert Walker; Willem Hanekom; Mark Hatherill; Hassan Mahomed Journal: Tuberculosis (Edinb) Date: 2013-02-12 Impact factor: 3.131
Authors: Collins Odhiambo; Clement Zeh; Pascale Ondoa; Paul Omolo; Benta Akoth; Humphrey Lwamba; Richard Lando; John Williamson; Juliana Otieno; Rose Masaba; Paul Weidle; Timothy Thomas Journal: PLoS One Date: 2015-11-03 Impact factor: 3.240
Authors: Helen McShane; Alison M Elliott; Anne Wajja; Milly Namutebi; Barbara Apule; Gloria Oduru; Samuel Kiwanuka; Mirriam Akello; Beatrice Nassanga; Joyce Kabagenyi; Juma Mpiima; Samantha Vermaak; Alison Lawrie; Iman Satti; Jaco Verweij; Stephen Cose; Jonathan Levin; Pontiano Kaleebu; Edridah Tukahebwa Journal: Wellcome Open Res Date: 2018-09-19