AIMS: To evaluate health-related quality of life (HRQoL) in celiac disease (CD) patients at the time of diagnosis and during a gluten-free diet (GFD). PATIENTS AND METHODS: We enrolled 43 adult CD patients (18 with a typical and 15 with an atypical clinical presentation, and 10 with dermatitis herpetiformis, DH) and 86 age- and sex-matched healthy controls. We administered the Short Form 36 Health Survey (SF-36) questionnaire at diagnosis and after 1, 12 and 24 months of a GFD. RESULTS: At the time of diagnosis CD patients showed significantly lower SF-36 scores than controls; this figure was observed in women but not in men. At baseline, both typical and atypical CD patients had lower SF-36 scores than controls, while DH patients showed a SF-36 profile comparable to that of controls. During a GFD the SF-36 scores improved continuously in CD patients and in the female subgroup, becoming similar to those of matched controls at 1-year follow-up. After gluten withdrawal typical and atypical CD patients improved their SF-36 scores and reached values comparable to those of controls. CONCLUSIONS: At diagnosis, CD patients perceived a poor HRQoL; this figure appears to be mostly associated with female gender. In all subgroups of CD patients with a low HRQoL at diagnosis, the GFD allowed progressive restoration of HRQoL perception.
AIMS: To evaluate health-related quality of life (HRQoL) in celiac disease (CD) patients at the time of diagnosis and during a gluten-free diet (GFD). PATIENTS AND METHODS: We enrolled 43 adult CDpatients (18 with a typical and 15 with an atypical clinical presentation, and 10 with dermatitis herpetiformis, DH) and 86 age- and sex-matched healthy controls. We administered the Short Form 36 Health Survey (SF-36) questionnaire at diagnosis and after 1, 12 and 24 months of a GFD. RESULTS: At the time of diagnosis CDpatients showed significantly lower SF-36 scores than controls; this figure was observed in women but not in men. At baseline, both typical and atypical CDpatients had lower SF-36 scores than controls, while DHpatients showed a SF-36 profile comparable to that of controls. During a GFD the SF-36 scores improved continuously in CDpatients and in the female subgroup, becoming similar to those of matched controls at 1-year follow-up. After gluten withdrawal typical and atypical CDpatients improved their SF-36 scores and reached values comparable to those of controls. CONCLUSIONS: At diagnosis, CDpatients perceived a poor HRQoL; this figure appears to be mostly associated with female gender. In all subgroups of CDpatients with a low HRQoL at diagnosis, the GFD allowed progressive restoration of HRQoL perception.
Authors: Katrina Nordyke; Fredrik Norström; Lars Lindholm; Hans Stenlund; Anna Rosén; Anneli Ivarsson Journal: BMC Public Health Date: 2013-02-16 Impact factor: 3.295
Authors: Josefa Barrio; Maria Luz Cilleruelo; Enriqueta Román; Cristina Fernández Journal: Health Qual Life Outcomes Date: 2020-07-25 Impact factor: 3.186
Authors: Jonas F Ludvigsson; Carolina Ciacci; Peter Hr Green; Katri Kaukinen; Ilma R Korponay-Szabo; Kalle Kurppa; Joseph A Murray; Knut Erik Aslaksen Lundin; Markku J Maki; Alina Popp; Norelle R Reilly; Alfonso Rodriguez-Herrera; David S Sanders; Detlef Schuppan; Sarah Sleet; Juha Taavela; Kristin Voorhees; Marjorie M Walker; Daniel A Leffler Journal: Gut Date: 2018-02-13 Impact factor: 23.059