Literature DB >> 205876

Purification of nuclear antigens in Novikoff hepatoma.

H Fujitani, J F Chiu, L S Hnilica.   

Abstract

Nuclear antigen in Novikoff hepatoma chromatin was partially purified and characterized. As indicated by complement fixation assay, this antigen was present in chromatin of embryonic livers and several transplantable tumors. It was not detected in normal tissue chromatins of the same animals. For its immunological specificity this protein antigen (molecular weight 45,000-60,000) had to be complexed with DNA. Preliminary experiments indicate that specific nuclear protein antigens are also present in human tissues and spontaneous malignancies.

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Year:  1978        PMID： 205876      PMCID： PMC392458          DOI： 10.1073/pnas.75.4.1943

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

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Journal:  Z Rheumaforsch       Date:  1962-02

2.  Quantitative micro-complement fixation and its use in the study of antigenic structure by specific antigen-antibody inhibition.

Authors:  E WASSERMAN; L LEVINE
Journal:  J Immunol       Date:  1961-09       Impact factor: 5.422

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Authors:  L MESSINEO
Journal:  Nature       Date:  1961-06-17       Impact factor: 49.962

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Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

5.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

6.  Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels.

Authors:  A L Shapiro; E Viñuela; J V Maizel
Journal:  Biochem Biophys Res Commun       Date:  1967-09-07       Impact factor: 3.575

7.  Purification and characterization of two major DNA-binding proteins in human serum.

Authors:  S O Hoch; E McVey
Journal:  J Biol Chem       Date:  1977-03-25       Impact factor: 5.157

8.  Purification and identification of a human-serum DNA-binding protein associated with malignant diseases.

Authors:  R G Parsons; J A Hoch
Journal:  Eur J Biochem       Date:  1976-12

9.  Tissue-specific antibodies against human lung and breast carcinoma dehistonized chromatins.

Authors:  J F Chiu; L S Hnilica; F Chytil; J T Orrahood; L W Rogers
Journal:  J Natl Cancer Inst       Date:  1977-07       Impact factor: 13.506

10.  A fetal protein in chromatin of Novikoff hepatoma and Walker 256 carcinosarcoma tumors that is absent from normal and regenerating rat liver.

Authors:  L C Yeoman; J J Jordan; R K Busch; C W Taylor; H E Savage; H Busch
Journal:  Proc Natl Acad Sci U S A       Date:  1976-09       Impact factor: 11.205
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  4 in total

1.  Identification of cytokeratin antigens in Novikoff ascites hepatoma.

Authors:  W N Schmidt; R L Pardue; M C Tutt; R C Briggs; B R Brinkley; L S Hnilica
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

2.  Cell specific antiserum to chromosome scaffold proteins.

Authors:  A M Campbell; R C Briggs; R E Bird; L S Hnilica
Journal:  Nucleic Acids Res       Date:  1979-01       Impact factor: 16.971

3.  Association of cytokeratin p39 with DNA in intact Novikoff hepatoma cells.

Authors:  W S Ward; W N Schmidt; C A Schmidt; L S Hnilica
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

4.  Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.

Authors:  D A Stetler; K M Rose; S T Jacob
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205
  4 in total

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