Literature DB >> 20587346

The immunogenicity of therapeutic proteins.

Huub Schellekens1.   

Abstract

Nearly all therapeutic proteins induce antibodies in patients. However this immunogenicity has been neglected in the use of these products, even though the antibodies may have severe consequences. During the last few years, progress has been made in understanding why patients do not tolerate these protein therapeutic products and also how to manage the problem of immunogenicity.

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Year:  2010        PMID： 20587346

Source DB:  PubMed          Journal:  Discov Med        ISSN： 1539-6509            Impact factor:   2.970


  32 in total

Review 1.  Immunogenicity of subcutaneously administered therapeutic proteins--a mechanistic perspective.

Authors:  Anas M Fathallah; Richard B Bankert; Sathy V Balu-Iyer
Journal:  AAPS J       Date:  2013-07-16       Impact factor: 4.009

Review 2.  Erythrocyte-mediated delivery of recombinant enzymes.

Authors:  Vincenzo Leuzzi; Luigia Rossi; Claudia Gabucci; Francesca Nardecchia; Mauro Magnani
Journal:  J Inherit Metab Dis       Date:  2016-03-30       Impact factor: 4.982

3.  A Flow-Cytometry-Based Approach to Facilitate Quantification, Size Estimation and Characterization of Sub-visible Particles in Protein Solutions.

Authors:  Christian Lubich; Mantas Malisauskas; Thomas Prenninger; Thomas Wurz; Peter Matthiessen; Peter L Turecek; Friedrich Scheiflinger; Birgit M Reipert
Journal:  Pharm Res       Date:  2015-03-19       Impact factor: 4.200

Review 4.  Design and engineering of deimmunized biotherapeutics.

Authors:  Karl E Griswold; Chris Bailey-Kellogg
Journal:  Curr Opin Struct Biol       Date:  2016-06-17       Impact factor: 6.809

5.  Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles.

Authors:  Takashi K Kishimoto; Joseph D Ferrari; Robert A LaMothe; Pallavi N Kolte; Aaron P Griset; Conlin O'Neil; Victor Chan; Erica Browning; Aditi Chalishazar; William Kuhlman; Fen-Ni Fu; Nelly Viseux; David H Altreuter; Lloyd Johnston; Roberto A Maldonado
Journal:  Nat Nanotechnol       Date:  2016-08-01       Impact factor: 39.213

Review 6.  Bioconjugate Strategies for the Induction of Antigen-Specific Tolerance in Autoimmune Diseases.

Authors:  Chunsong Yu; Jingchao Xi; Meng Li; Myunggi An; Haipeng Liu
Journal:  Bioconjug Chem       Date:  2017-12-06       Impact factor: 4.774

7.  Significance of unfolding thermodynamics for predicting aggregation kinetics: a case study on high concentration solutions of a multi-domain protein.

Authors:  Atul Saluja; Vikram Sadineni; Amol Mungikar; Vishal Nashine; Andrew Kroetsch; Charles Dahlheim; Venkatramana M Rao
Journal:  Pharm Res       Date:  2014-01-08       Impact factor: 4.200

8.  Deimmunized Lysostaphin Synergizes with Small-Molecule Chemotherapies and Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics.

Authors:  Yongliang Fang; Jack R Kirsch; Liang Li; Seth A Brooks; Spencer Heim; Cynthia Tan; Susan Eszterhas; Hao D Cheng; Hongliang Zhao; Yan Q Xiong; Karl E Griswold
Journal:  Antimicrob Agents Chemother       Date:  2021-02-17       Impact factor: 5.191

9.  A novel approach to evaluate the pharmacokinetic biocomparability of a monoclonal antibody derived from two different cell lines using simultaneous crossover design.

Authors:  Chao Han; Thomas S McIntosh; Brian J Geist; Trina Jiao; Thomas A Puchalski; Kenneth M Goldberg; Tong-Yuan Yang; Charles E Pendley; Honghui Zhou; Hugh M Davis
Journal:  AAPS J       Date:  2013-11-27       Impact factor: 4.009

10.  Thiol-disulfide exchange in peptides derived from human growth hormone.

Authors:  Saradha Chandrasekhar; Daniel E Epling; Andreas M Sophocleous; Elizabeth M Topp
Journal:  J Pharm Sci       Date:  2014-02-18       Impact factor: 3.534
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