Literature DB >> 20585042

A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets.

Dafydd H Thomas1, Todd M Getz, Tiffanny N Newman, Carol A Dangelmaier, Nick Carpino, Satya P Kunapuli, Alexander Y Tsygankov, James L Daniel.   

Abstract

T-cell ubiquitin ligand-2 (TULA-2) is a recently discovered histidine tyrosine phosphatase thought to be ubiquitously expressed. In this work, we have investigated whether TULA-2 has a key role in platelet glycoprotein VI (GPVI) signaling. This study indicates that TULA-2 is expressed in human and murine platelets and is able to associate with Syk and dephosphorylate it. Ablation of TULA-2 resulted in hyperphosphorylation of Syk and its downstream effector phospholipase C-γ2 as well as enhanced GPVI-mediated platelet functional responses. In addition, shorter bleeding times and a prothrombotic phenotype were observed in mice lacking TULA-2. We therefore propose that TULA-2 is the primary tyrosine phosphatase mediating the dephosphorylation of Syk and thus functions as a negative regulator of GPVI signaling in platelets.

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Year:  2010        PMID： 20585042      PMCID： PMC2953889          DOI： 10.1182/blood-2010-02-268136

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  32 in total

1.  TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.

Authors:  Elena A Feshchenko; Evgeniya V Smirnova; Gayathri Swaminathan; Anjali M Teckchandani; Rachana Agrawal; Hamid Band; Xiaolong Zhang; Roland S Annan; Steven A Carr; Alexander Y Tsygankov
Journal:  Oncogene       Date:  2004-06-10       Impact factor: 9.867

2.  Collagen stimulates tyrosine phosphorylation of phospholipase C-gamma 2 but not phospholipase C-gamma 1 in human platelets.

Authors:  R A Blake; G L Schieven; S P Watson
Journal:  FEBS Lett       Date:  1994-10-17       Impact factor: 4.124

3.  Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein.

Authors:  Nick Carpino; Ryuji Kobayashi; Heesuk Zang; Yutaka Takahashi; Shiann-Tarrng Jou; Jian Feng; Hideaki Nakajima; James N Ihle
Journal:  Mol Cell Biol       Date:  2002-11       Impact factor: 4.272

4.  Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains.

Authors:  M Wattenhofer; K Shibuya; J Kudoh; R Lyle; J Michaud; C Rossier; K Kawasaki; S Asakawa; S Minoshima; A Berry; B Bonne-Tamir; N Shimizu; S E Antonarakis; H S Scott
Journal:  Hum Genet       Date:  2001-02       Impact factor: 4.132

Review 5.  Platelet-collagen interaction: is GPVI the central receptor?

Authors:  Bernhard Nieswandt; Steve P Watson
Journal:  Blood       Date:  2003-03-20       Impact factor: 22.113

6.  A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1.

Authors:  P Mangin; C Nonne; A Eckly; P Ohlmann; M Freund; B Nieswandt; J P Cazenave; C Gachet; F Lanza
Journal:  FEBS Lett       Date:  2003-05-08       Impact factor: 4.124

7.  Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization.

Authors:  J L Daniel; C Dangelmaier; J B Smith
Journal:  Biochem J       Date:  1994-09-01       Impact factor: 3.857

8.  Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2.

Authors:  Nick Carpino; Steve Turner; Divya Mekala; Yutaka Takahashi; Heesuk Zang; Terrence L Geiger; Peter Doherty; James N Ihle
Journal:  Immunity       Date:  2004-01       Impact factor: 31.745

9.  Activation of phospholipase Cgamma2 by tyrosine phosphorylation.

Authors:  Fatih Ozdener; Carol Dangelmaier; Barrie Ashby; Satya P Kunapuli; James L Daniel
Journal:  Mol Pharmacol       Date:  2002-09       Impact factor: 4.436

10.  CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo.

Authors:  Cyndi Wong; Yong Liu; Jana Yip; Rochna Chand; Janet L Wee; Lisa Oates; Bernhard Nieswandt; Adili Reheman; Heyu Ni; Nicole Beauchemin; Denise E Jackson
Journal:  Blood       Date:  2008-11-13       Impact factor: 22.113
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  27 in total

1.  Increased Resistance to Intradermal Francisella tularensis LVS Infection by Inactivation of the Sts Phosphatases.

Authors:  Kaustubh Parashar; Erik Kopping; David Frank; Vinaya Sampath; David G Thanassi; Nick Carpino
Journal:  Infect Immun       Date:  2017-08-18       Impact factor: 3.441

2.  Gq pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets.

Authors:  Rachit Badolia; Vaishali Inamdar; Bhanu Kanth Manne; Carol Dangelmaier; Johannes A Eble; Satya P Kunapuli
Journal:  J Biol Chem       Date:  2017-07-13       Impact factor: 5.157

3.  TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function.

Authors:  Steven H Back; Naga Suresh Adapala; Mary F Barbe; Nick C Carpino; Alexander Y Tsygankov; Archana Sanjay
Journal:  Cell Mol Life Sci       Date:  2012-11-13       Impact factor: 9.261

4.  Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation.

Authors:  Rodrigo Orlandini de Castro; Juan Zhang; Jacqueline R Groves; Emilia Alina Barbu; Reuben P Siraganian
Journal:  J Biol Chem       Date:  2012-01-20       Impact factor: 5.157

5.  Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice.

Authors:  Yuhang Zhou; Shaji Abraham; Pierrette Andre; Leonard C Edelstein; Chad A Shaw; Carol A Dangelmaier; Alexander Y Tsygankov; Satya P Kunapuli; Paul F Bray; Steven E McKenzie
Journal:  Blood       Date:  2015-10-29       Impact factor: 22.113

6.  Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition.

Authors:  Florian Beck; Jörg Geiger; Stepan Gambaryan; Fiorella A Solari; Margherita Dell'Aica; Stefan Loroch; Nadine J Mattheij; Igor Mindukshev; Oliver Pötz; Kerstin Jurk; Julia M Burkhart; Christian Fufezan; Johan W M Heemskerk; Ulrich Walter; René P Zahedi; Albert Sickmann
Journal:  Blood       Date:  2016-11-09       Impact factor: 22.113

7.  TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.

Authors:  Kevin Reppschläger; Jeanne Gosselin; Carol A Dangelmaier; Dafydd H Thomas; Nick Carpino; Steven E McKenzie; Satya P Kunapuli; Alexander Y Tsygankov
Journal:  J Biol Chem       Date:  2016-09-08       Impact factor: 5.157

Review 8.  Advances in development of new tools for the study of phosphohistidine.

Authors:  Mehul V Makwana; Richmond Muimo; Richard Fw Jackson
Journal:  Lab Invest       Date:  2017-12-04       Impact factor: 5.662

9.  Insights into the suppressor of T-cell receptor (TCR) signaling-1 (Sts-1)-mediated regulation of TCR signaling through the use of novel substrate-trapping Sts-1 phosphatase variants.

Authors:  Boris S Luis; Nick Carpino
Journal:  FEBS J       Date:  2013-12-12       Impact factor: 5.542

10.  Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms.

Authors:  Lorena Buitrago; Dheeraj Bhavanasi; Carol Dangelmaier; Bhanu Kanth Manne; Rachit Badolia; Alessandra Borgognone; Alexander Y Tsygankov; Steven E McKenzie; Satya P Kunapuli
Journal:  J Biol Chem       Date:  2013-08-19       Impact factor: 5.157
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