Literature DB >> 20584959

Trauma-induced coagulopathy in severely injured patients: knowledge lost in translation?

Victor Jeger1, Natalie Urwyler, Heinz Zimmermann, Aristomenis K Exadaktylos.   

Abstract

BACKGROUND: Many guidelines exist on how to treat patients with multiple injuries correctly in an accident and emergency setting. The aim of the present work was to find out how well patients are treated focusing on trauma induced coagulopathy (TIC), and what anaesthetists involved in trauma care think about their own experiences with TIC.
METHODS: In a retrospective chart review of patients with an Injury Severity Score (ISS) > or = 16 between October 2007 and October 2008. A total of 172 patients with multiple injuries (134 men, 38 women) were treated in the resuscitation room and underwent complete coagulation screening (international normalised ratio (INR), activated partial thromboplastin time (aPTT), thrombin time (TT)). The presence of TIC was defined as INR>1.5 and aPTT>60 s or TT>15 s. Additionally, during the weekly anaesthesia and critical care grand round, a short questionnaire about TIC management was distributed to all anaesthetists involved in trauma care.
RESULTS: Of the 172 patients with multiple injuries, 56 (32.6%) had TIC at admission to the resuscitation bay and 7 of these 56 (12.5%) received fresh-frozen plasma in the first hour of treatment. The mean of 55 anaesthetists thought that TIC could be corrected within about 30 min, although a chart review shows that it takes about 60 min to get complete laboratory based coagulation screening results. However, 70% of the doctors are not satisfied with the laboratory results they receive concerning TIC.
CONCLUSIONS: There is an obvious discrepancy between the content of guidelines and the everyday practice. Future academic efforts in the area of trauma care should therefore focus more on the translational approach and the implementation of existing knowledge rather than on simply formulating guidelines.

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Year:  2010        PMID: 20584959     DOI: 10.1136/emj.2009.075994

Source DB:  PubMed          Journal:  Emerg Med J        ISSN: 1472-0205            Impact factor:   2.740


  5 in total

Review 1.  The pathophysiology, diagnosis and treatment of the acute coagulopathy of trauma and shock: a literature review.

Authors:  J Kaczynski; M Wilczynska; L Fligelstone; J Hilton
Journal:  Eur J Trauma Emerg Surg       Date:  2013-12-12       Impact factor: 3.693

2.  Effect of haematocrit on fibrin-based clot firmness in the FIBTEM test.

Authors:  Cristina Solomon; Niels Rahe-Meyer; Herbert Schöchl; Marco Ranucci; Klaus Görlinger
Journal:  Blood Transfus       Date:  2012-11-20       Impact factor: 3.443

3.  The role of thrombelastography in multiple trauma.

Authors:  Victor Jeger; Heinz Zimmermann; Aristomenis K Exadaktylos
Journal:  Emerg Med Int       Date:  2011-09-07       Impact factor: 1.112

4.  The Rapid TEG α-Angle may be a sensitive predictor of transfusion in moderately injured blunt trauma patients.

Authors:  Victor Jeger; Sandra Willi; Tun Liu; Daniel D Yeh; Marc De Moya; Heinz Zimmermann; Aristomenis K Exadaktylos
Journal:  ScientificWorldJournal       Date:  2012-04-01

5.  Rapid measurement of fibrinogen concentration in whole blood using a steel ball coagulometer.

Authors:  Christoph J Schlimp; Anna Khadem; Anton Klotz; Cristina Solomon; Gerald Hochleitner; Martin Ponschab; Heinz Redl; Herbert Schöchl
Journal:  J Trauma Acute Care Surg       Date:  2015-04       Impact factor: 3.313

  5 in total

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