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Literature DB >> 2058467

Influence of no-donor (SIN-1) on functions of inflammatory cells.

A Dembińska-Kieć¹, A Zmuda, J Marcinkiewicz, H Sinzinger, R J Gryglewski.

Abstract

NO-donor SIN-1 (0.01-1.0 mM) dose-dependently inhibited the basal and FMLP (30.0 mM)-stimulated release of beta-glucuronidase from rat peritoneal leukocytes and antigen-specific stimulation of Interleukin-2 production by T-hybridomas. I-123 LDL binding to human lymphocytes was inhibited by Iloprost (1 mM) but activated by SIN-1 (0.3 mM). We conclude that beside the smooth muscle cells and platelets the blood inflammatory/immune cells are under the PGI2/NO control, however, the precise regulation as well as physiological importance need further investigation.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 1991 PMID： 2058467 DOI： 10.1007/bf01983305

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

17 in total

1. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Authors: L J Ignarro; G M Buga; K S Wood; R E Byrns; G Chaudhuri
Journal: Proc Natl Acad Sci U S A Date: 1987-12 Impact factor: 11.205

2. Cytoprotection of human polymorphonuclear leukocytes by stimulators of adenylate and guanylate cyclases.

Authors: R Korbut; E Trabka-Janik; R J Gryglewski
Journal: Eur J Pharmacol Date: 1989-06-08 Impact factor: 4.432

3. Plasma lipoproteins can suppress accessory cell function and consequently suppress lymphocyte activation.

Authors: T Nakayasu; M Macy; Y Okano; B M McCarthy; J A Harmony
Journal: Exp Cell Res Date: 1986-03 Impact factor: 3.905

4. Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor.

Authors: D Salvemini; G de Nucci; R J Gryglewski; J R Vane
Journal: Proc Natl Acad Sci U S A Date: 1989-08 Impact factor: 11.205

5. Regulation of low-density lipoprotein receptors: implications for pathogenesis and therapy of hypercholesterolemia and atherosclerosis.

Authors: J L Goldstein; M S Brown
Journal: Circulation Date: 1987-09 Impact factor: 29.690

Influence of no-donor (SIN-1) on functions of inflammatory cells.

1. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

2. Cytoprotection of human polymorphonuclear leukocytes by stimulators of adenylate and guanylate cyclases.

3. Plasma lipoproteins can suppress accessory cell function and consequently suppress lymphocyte activation.

4. Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor.

5. Regulation of low-density lipoprotein receptors: implications for pathogenesis and therapy of hypercholesterolemia and atherosclerosis.

6. Chemokinetic activity of arachidonic and lipoxygenase products on leuocyctes of different species.

7. Beneficial effects of a new carbacyclin derivative, ZK 36 374, in acute myocardial ischemia.

8. An improved colorimetric assay for interleukin 2.

9. Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron.

10. Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1. Induction of nitric oxide synthase activity by toxic shock syndrome toxin 1 in a macrophage-monocyte cell line.