| Literature DB >> 20584610 |
Hai-Yun Xiao1, Aaron Balog, Ricardo M Attar, David Fairfax, Linda B Fleming, Christian L Holst, Gregory S Martin, Lana M Rossiter, Jing Chen, Mary-Ellen Cvjic, Janet Dell-John, Jieping Geng, Marco M Gottardis, Wen-Ching Han, Andrew Nation, Mary Obermeier, Cheryl A Rizzo, Liang Schweizer, Thomas Spires, Weifang Shan, Ashvinikumar Gavai, Mark E Salvati, Gregory Vite.
Abstract
A novel series of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles has been synthesized. The ability of these compounds to act as antagonists of the androgen receptor was investigated and several were found to have potent activity in vitro and in vivo. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20584610 DOI： 10.1016/j.bmcl.2010.06.034
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823