Literature DB >> 20584374

Visualizing genetic similarity at the symptom level: the example of learning disabilities.

Oliver S P Davis1, Robert Plomin.   

Abstract

Psychological traits and disorders are often interrelated through shared genetic influences. A combination of maximum-likelihood structural equation modelling and multidimensional scaling enables us to open a window onto the genetic architecture at the symptom level, rather than at the level of latent genetic factors. We illustrate this approach using a study of cognitive abilities involving over 5,000 pairs of twins.

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Year:  2010        PMID: 20584374      PMCID: PMC3868893          DOI: 10.1017/S0140525X10000749

Source DB:  PubMed          Journal:  Behav Brain Sci        ISSN: 0140-525X            Impact factor:   12.579


  6 in total

Review 1.  Generalist genes and learning disabilities.

Authors:  Robert Plomin; Yulia Kovas
Journal:  Psychol Bull       Date:  2005-07       Impact factor: 17.737

2.  Learning abilities and disabilities: generalist genes in early adolescence.

Authors:  Oliver S P Davis; Claire M A Haworth; Robert Plomin
Journal:  Cogn Neuropsychiatry       Date:  2009       Impact factor: 1.871

Review 3.  Common disorders are quantitative traits.

Authors:  Robert Plomin; Claire M A Haworth; Oliver S P Davis
Journal:  Nat Rev Genet       Date:  2009-10-27       Impact factor: 53.242

4.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Authors: 
Journal:  Nature       Date:  2007-06-07       Impact factor: 49.962

5.  Twins' Early Development Study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behavior problems from childhood through adolescence.

Authors:  Bonamy R Oliver; Robert Plomin
Journal:  Twin Res Hum Genet       Date:  2007-02       Impact factor: 1.587

6.  Internet cognitive testing of large samples needed in genetic research.

Authors:  Claire M A Haworth; Nicole Harlaar; Yulia Kovas; Oliver S P Davis; Bonamy R Oliver; Marianna E Hayiou-Thomas; Jane Frances; Patricia Busfield; Andrew McMillan; Philip S Dale; Robert Plomin
Journal:  Twin Res Hum Genet       Date:  2007-08       Impact factor: 1.587

  6 in total

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