Literature DB >> 20582809

A new antitumour ansamitocin from Actinosynnema pretiosum.

Guo-Zhu Wei1, Lin-Quan Bai, Tao Yang, Juan Ma, Ying Zeng, Yue-Mao Shen, Pei-Ji Zhao.   

Abstract

A new compound of ansamitocin was isolated from the extracts of fermentation medium of mutant strain HGF052 derived from Actinosynnema pretiosum ssp. aurantium ATCC 31565, and identified as N-demethyl-desepoxy-9-methoxy-maytansinol (1) on the basis of extensive spectroscopic methods. Bioassay results showed that compound 1 had cytotoxic activity against HL-60 and BEL-7402 cell lines.

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Year:  2010        PMID: 20582809     DOI: 10.1080/14786410902916552

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN: 1478-6419            Impact factor:   2.861


  3 in total

1.  Improved l-phenylglycine synthesis by introducing an engineered cofactor self-sufficient system.

Authors:  Pengchao Wang; Xiwen Zhang; Yucheng Tao; Xubing Lv; Shengjie Cheng; Chengwei Liu
Journal:  Synth Syst Biotechnol       Date:  2021-12-22

2.  Non-streptomycete actinomycetes nourish the current microbial antibiotic drug discovery.

Authors:  Polpass Arul Jose; Solomon Robinson David Jebakumar
Journal:  Front Microbiol       Date:  2013-08-20       Impact factor: 5.640

3.  p-Aminophenylalanine Involved in the Biosynthesis of Antitumor Dnacin B1 for Quinone Moiety Formation.

Authors:  Xiaojing Hu; Xing Li; Yong Sheng; Hengyu Wang; Xiaobin Li; Yixin Ou; Zixin Deng; Linquan Bai; Qianjin Kang
Journal:  Molecules       Date:  2020-09-12       Impact factor: 4.411

  3 in total

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