Literature DB >> 20581876

Hints of hidden heritability in GWAS.

Greg Gibson.   

Abstract

Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.

Mesh：

Year:  2010        PMID： 20581876     DOI： 10.1038/ng0710-558

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  8 in total

1.  Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk.

Authors:  David M Evans; Peter M Visscher; Naomi R Wray
Journal:  Hum Mol Genet       Date:  2009-06-24       Impact factor: 6.150

2.  Common SNPs explain a large proportion of the heritability for human height.

Authors:  Jian Yang; Beben Benyamin; Brian P McEvoy; Scott Gordon; Anjali K Henders; Dale R Nyholt; Pamela A Madden; Andrew C Heath; Nicholas G Martin; Grant W Montgomery; Michael E Goddard; Peter M Visscher
Journal:  Nat Genet       Date:  2010-06-20       Impact factor: 38.330

3.  Estimation of effect size distribution from genome-wide association studies and implications for future discoveries.

Authors:  Ju-Hyun Park; Sholom Wacholder; Mitchell H Gail; Ulrike Peters; Kevin B Jacobs; Stephen J Chanock; Nilanjan Chatterjee
Journal:  Nat Genet       Date:  2010-06-20       Impact factor: 38.330

Review 4.  Reaching new heights: insights into the genetics of human stature.

Authors:  Michael N Weedon; Timothy M Frayling
Journal:  Trends Genet       Date:  2008-10-22       Impact factor: 11.639

5.  The genetic interpretation of area under the ROC curve in genomic profiling.

Authors:  Naomi R Wray; Jian Yang; Michael E Goddard; Peter M Visscher
Journal:  PLoS Genet       Date:  2010-02-26       Impact factor: 5.917

Review 6.  Finding the missing heritability of complex diseases.

Authors:  Teri A Manolio; Francis S Collins; Nancy J Cox; David B Goldstein; Lucia A Hindorff; David J Hunter; Mark I McCarthy; Erin M Ramos; Lon R Cardon; Aravinda Chakravarti; Judy H Cho; Alan E Guttmacher; Augustine Kong; Leonid Kruglyak; Elaine Mardis; Charles N Rotimi; Montgomery Slatkin; David Valle; Alice S Whittemore; Michael Boehnke; Andrew G Clark; Evan E Eichler; Greg Gibson; Jonathan L Haines; Trudy F C Mackay; Steven A McCarroll; Peter M Visscher
Journal:  Nature       Date:  2009-10-08       Impact factor: 49.962

Review 7.  Missing heritability and strategies for finding the underlying causes of complex disease.

Authors:  Evan E Eichler; Jonathan Flint; Greg Gibson; Augustine Kong; Suzanne M Leal; Jason H Moore; Joseph H Nadeau
Journal:  Nat Rev Genet       Date:  2010-06       Impact factor: 53.242

8.  Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

Authors:  Shaun M Purcell; Naomi R Wray; Jennifer L Stone; Peter M Visscher; Michael C O'Donovan; Patrick F Sullivan; Pamela Sklar
Journal:  Nature       Date:  2009-07-01       Impact factor: 49.962
  8 in total
  131 in total

1.  The problems and promises of research into human immunology and autoimmune disease.

Authors:  Bart O Roep; Jane Buckner; Stephen Sawcer; Rene Toes; Frauke Zipp
Journal:  Nat Med       Date:  2012-01-06       Impact factor: 53.440

2.  Linkage-disequilibrium-based binning affects the interpretation of GWASs.

Authors:  Andrea Christoforou; Michael Dondrup; Morten Mattingsdal; Manuel Mattheisen; Sudheer Giddaluru; Markus M Nöthen; Marcella Rietschel; Sven Cichon; Srdjan Djurovic; Ole A Andreassen; Inge Jonassen; Vidar M Steen; Pål Puntervoll; Stéphanie Le Hellard
Journal:  Am J Hum Genet       Date:  2012-03-22       Impact factor: 11.025

3.  To identify associations with rare variants, just WHaIT: Weighted haplotype and imputation-based tests.

Authors:  Yun Li; Andrea E Byrnes; Mingyao Li
Journal:  Am J Hum Genet       Date:  2010-11-04       Impact factor: 11.025

4.  GCTA: a tool for genome-wide complex trait analysis.

Authors:  Jian Yang; S Hong Lee; Michael E Goddard; Peter M Visscher
Journal:  Am J Hum Genet       Date:  2010-12-17       Impact factor: 11.025

5.  Genome-Wide Association Mapping and Genomic Prediction Elucidate the Genetic Architecture of Morphological Traits in Arabidopsis.

Authors:  Rik Kooke; Willem Kruijer; Ralph Bours; Frank Becker; André Kuhn; Henri van de Geest; Jaap Buntjer; Timo Doeswijk; José Guerra; Harro Bouwmeester; Dick Vreugdenhil; Joost J B Keurentjes
Journal:  Plant Physiol       Date:  2016-02-11       Impact factor: 8.340

6.  Behavioral idiosyncrasy reveals genetic control of phenotypic variability.

Authors:  Julien F Ayroles; Sean M Buchanan; Chelsea O'Leary; Kyobi Skutt-Kakaria; Jennifer K Grenier; Andrew G Clark; Daniel L Hartl; Benjamin L de Bivort
Journal:  Proc Natl Acad Sci U S A       Date:  2015-05-07       Impact factor: 11.205

7.  Integrative pathway analysis of a genome-wide association study of (V)O(2max) response to exercise training.

Authors:  Sujoy Ghosh; Juan C Vivar; Mark A Sarzynski; Yun Ju Sung; James A Timmons; Claude Bouchard; Tuomo Rankinen
Journal:  J Appl Physiol (1985)       Date:  2013-08-29

8.  A novel variational Bayes multiple locus Z-statistic for genome-wide association studies with Bayesian model averaging.

Authors:  Benjamin A Logsdon; Cara L Carty; Alexander P Reiner; James Y Dai; Charles Kooperberg
Journal:  Bioinformatics       Date:  2012-05-04       Impact factor: 6.937

9.  What can we learn from inflammatory bowel disease in developing countries?

Authors:  Sunny H Wong; Siew C Ng
Journal:  Curr Gastroenterol Rep       Date:  2013-03

Review 10.  The genetic basis for interindividual immune response variation to measles vaccine: new understanding and new vaccine approaches.

Authors:  Iana H Haralambieva; Inna G Ovsyannikova; V Shane Pankratz; Richard B Kennedy; Robert M Jacobson; Gregory A Poland
Journal:  Expert Rev Vaccines       Date:  2013-01       Impact factor: 5.217
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