| Literature DB >> 20580950 |
Tae Il Son1, Makoto Sakuragi, Sawa Takahashi, Sei Obuse, Jeonghwa Kang, Masako Fujishiro, Haruhiko Matsushita, Jiansheng Gong, Shigeru Shimizu, Yusuke Tajima, Yasuhiro Yoshida, Kazuomi Suzuki, Toshio Yamamoto, Mariko Nakamura, Yoshihiro Ito.
Abstract
A novel visible light-crosslinkable porcine gelatin was prepared for gelation and micropatterning. The preparation employed a photo-oxidation-induced crosslinking mechanism. First, furfuryl groups were incorporated into the gelatin. Second, the modified gelatin was mixed in water with Rose Bengal, which is a visible light sensitizer. Irradiation by visible light solidified the aqueous solution. In addition, when the solution was cast on a plate, dried and photo-irradiated in the presence of a photomask a micropattern was formed that matched the micropattern on the photomask. The gelatin-immobilized regions enhanced cell adhesion. It was also confirmed that the gelatin incorporating furfuryl and Rose Bengal have no significant toxicity. The photo-crosslinkable gelatin was employed as a direct pulp capping material in the dental field. Considering these results, this system could be useful as a new type of visible light-induced crosslinkable biosealant. 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20580950 DOI： 10.1016/j.actbio.2010.05.018
Source DB: PubMed Journal: Acta Biomater ISSN： 1742-7061 Impact factor: 8.947