| Literature DB >> 20580727 |
Abstract
Mathematical models of pancreatic beta cells suggest design principles that can be applied to engineering cells to sense glucose and secrete insulin. Engineering cells can potentially both contribute to future diabetes therapies and generate new insights into beta-cell function. The focus is on ion channels, Ca(2+)handling, and elements of metabolism that combine to produce the varied oscillatory patterns exhibited by beta cells. Copyright 2010. Published by Elsevier Inc.Entities:
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Year: 2010 PMID： 20580727 PMCID： PMC2918698 DOI： 10.1016/j.mbs.2010.05.005
Source DB: PubMed Journal: Math Biosci ISSN： 0025-5564 Impact factor: 2.144