Ediz Deniz1, Ulker Guc, Nesimi Buyukbabani, Ahmet Gul. 1. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey. edizdeniz@gmail.com
Abstract
OBJECTIVE: The aim was to investigate heat shock protein 60 (HSP60) expression in oral ulcerations of Behçet's disease (BD). STUDY DESIGN: Biopsy specimens were obtained from patients with BD (n = 11), recurrent aphthous stomatitis (RAS) (n = 11), oral lichen planus (OLP) (n = 11) and healthy individuals (HI) (n = 11). Eight samples in BD and RAS groups were evaluable. All groups were analyzed by biotin streptavidin-aminoethylcarbazole using monoclonal mouse antibodies to HSP60 Ab-1 (clone LK1). RESULTS: Immunostaining indicative of HSP60 expression in BD and RAS were significantly higher than HI. No significant difference was found between BD and OLP except in the suprabasal layer of epithelium. CONCLUSIONS: Altered expression of HSP60 was found in ulcerative lesions of BD and RAS suggesting that HSP60 has an association with the etiology or chronicity of these inflammatory lesions. Copyright 2010 Mosby, Inc. All rights reserved.
OBJECTIVE: The aim was to investigate heat shock protein 60 (HSP60) expression in oral ulcerations of Behçet's disease (BD). STUDY DESIGN: Biopsy specimens were obtained from patients with BD (n = 11), recurrent aphthous stomatitis (RAS) (n = 11), oral lichen planus (OLP) (n = 11) and healthy individuals (HI) (n = 11). Eight samples in BD and RAS groups were evaluable. All groups were analyzed by biotin streptavidin-aminoethylcarbazole using monoclonal mouse antibodies to HSP60 Ab-1 (clone LK1). RESULTS: Immunostaining indicative of HSP60 expression in BD and RAS were significantly higher than HI. No significant difference was found between BD and OLP except in the suprabasal layer of epithelium. CONCLUSIONS: Altered expression of HSP60 was found in ulcerative lesions of BD and RAS suggesting that HSP60 has an association with the etiology or chronicity of these inflammatory lesions. Copyright 2010 Mosby, Inc. All rights reserved.
Authors: Kamran B Lankarani; Mohammad Reza Ravanbod; Elham Aflaki; Mohammad Ali Nazarinia; Akbar Rajaee Journal: BMC Gastroenterol Date: 2014-03-31 Impact factor: 3.067