Literature DB >> 20580232

Synthesis, antidepressant evaluation and QSAR studies of novel 2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(substituted phenyl)acetamides.

Suhas M Shelke1, Sharad H Bhosale.   

Abstract

In search for novel antidepressants, a series of 2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(substituted phenyl)acetamides was synthesized and screened for potential antidepressant activity by tail suspension test (TST) in mice. Number of synthesized compounds exhibited impressive antidepressant activity, measured in terms of percentage decrease in immobility duration (%DID). QSAR analysis was also undertaken which correlated three parameters FOSA, PISA, and glob with biological activity. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20580232     DOI： 10.1016/j.bmcl.2010.05.100

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats.

Authors:  Urmila M Aswar; Padmaja P Kalshetti; Suhas M Shelke; Sharad H Bhosale; Subhash L Bodhankar
Journal:  Asian Pac J Trop Biomed       Date:  2012-12

2.  Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Authors:  Nadeem Siddiqui; Sandhya Bawa; Ruhi Ali; Obaid Afzal; M Jawaid Akhtar; Bishmillah Azad; Rajiv Kumar
Journal:  J Pharm Bioallied Sci       Date:  2011-04

Review 3.  Chemical Structure-Biological Activity Models for Pharmacophores' 3D-Interactions.

Authors:  Mihai V Putz; Corina Duda-Seiman; Daniel Duda-Seiman; Ana-Maria Putz; Iulia Alexandrescu; Maria Mernea; Speranta Avram
Journal:  Int J Mol Sci       Date:  2016-07-08       Impact factor: 5.923

4.  Design, Synthesis, and Biological Evaluation of 1,2,3-Triazole-Linked Triazino[5,6-B]Indole-Benzene Sulfonamide Conjugates as Potent Carbonic Anhydrase I, II, IX, and XIII Inhibitors.

Authors:  Krishna Kartheek Chinchilli; Andrea Angeli; Pavitra S Thacker; Laxman Naik Korra; Rashmita Biswas; Mohammed Arifuddin; Claudiu T Supuran
Journal:  Metabolites       Date:  2020-05-15

5.  New Triazinoindole Bearing Benzimidazole/Benzoxazole Hybrids Analogs as Potent Inhibitors of Urease: Synthesis, In Vitro Analysis and Molecular Docking Studies.

Authors:  Sundas Mumtaz; Shahid Iqbal; Mazloom Shah; Rafaqat Hussain; Fazal Rahim; Wajid Rehman; Shoaib Khan; Obaid-Ur-Rahman Abid; Liaqat Rasheed; Ayed A Dera; Hanan A Al-Ghulikah; Sana Kehili; Eslam B Elkaeed; Hamad Alrbyawi; Mohammed Issa Alahmdi
Journal:  Molecules       Date:  2022-10-04       Impact factor: 4.927

6.  Synthesis of Novel Triazinoindole-Based Thiourea Hybrid: A Study on α-Glucosidase Inhibitors and Their Molecular Docking.

Authors:  Muhammad Taha; Foziah J Alshamrani; Fazal Rahim; Shawkat Hayat; Hayat Ullah; Khalid Zaman; Syahrul Imran; Khalid Mohammed Khan; Farzana Naz
Journal:  Molecules       Date:  2019-10-23       Impact factor: 4.411
  6 in total

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