| Literature DB >> 20579985 |
Toshihiro Inoue1, Tetsushi Kagawa, Miyuki Inoue-Mochita, Kyoichi Isono, Naoki Ohtsu, Ikuo Nobuhisa, Mikiko Fukushima, Hidenobu Tanihara, Tetsuya Taga.
Abstract
Members of the homeodomain-interacting protein kinase (HIPK) family are involved in various intracellular regulatory mechanisms. The present study focused on clarifying the functions of HIPK family members in ocular organization during late embryogenesis. HIPK1 and HIPK2 were expressed in the inner retina during late embryogenesis. Hipk1(+/-)Hipk2(-/-) mice had a greater frequency of small eyes with a lens deficiency and abnormally laminated and thickened retinas than did wild-type littermates. These data indicate that Hipk1 and Hipk2 are involved in regulation of eye size, lens formation and retinal lamination during late embryogenesis. Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20579985 DOI： 10.1016/j.febslet.2010.06.020
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124