AIM: The present study was undertaken to determine the effects of type 2 diabetes (T2D) on plasma kallikrein activity (PKA) and postexercise hypotension (PEH). METHODS: Ten T2D patients (age: 53.6±1.3 years; body mass index: 30.6±1.0kg/m(2); resting blood glucose: 157.8±40.2mgdL(-1)) and 10 non-diabetic (ND) volunteers (age: 47.5±1.0 years; body mass index: 28.3±0.9kg/m(2); resting blood glucose: 91.2±10.5mgdL(-1)) underwent two experimental sessions, consisting of 20min of rest plus 20min of exercise (EXE) at an intensity corresponding to 90% of their lactate threshold (90LT) and a non-exercise control (CON) session. Blood pressure (BP; Microlife BP 3AC1-1 monitor) and PKA were measured during rest and every 15min for 135min of the postexercise recovery period (RP). RESULTS: During the RP, the ND individuals presented with PEH at 30, 45 and 120min (P<0.05) while, in the T2D patients, PEH was not observed at any time. PKA increased at 15min postexercise in the ND (P<0.05), but not in the T2D patients. CONCLUSION: T2D individuals have a lower PKA response to exercise, which probably suppresses its hypotensive effect, thus reinforcing the possible role of PKA on PEH.
AIM: The present study was undertaken to determine the effects of type 2 diabetes (T2D) on plasma kallikrein activity (PKA) and postexercise hypotension (PEH). METHODS: Ten T2D patients (age: 53.6±1.3 years; body mass index: 30.6±1.0kg/m(2); resting blood glucose: 157.8±40.2mgdL(-1)) and 10 non-diabetic (ND) volunteers (age: 47.5±1.0 years; body mass index: 28.3±0.9kg/m(2); resting blood glucose: 91.2±10.5mgdL(-1)) underwent two experimental sessions, consisting of 20min of rest plus 20min of exercise (EXE) at an intensity corresponding to 90% of their lactate threshold (90LT) and a non-exercise control (CON) session. Blood pressure (BP; Microlife BP 3AC1-1 monitor) and PKA were measured during rest and every 15min for 135min of the postexercise recovery period (RP). RESULTS: During the RP, the ND individuals presented with PEH at 30, 45 and 120min (P<0.05) while, in the T2D patients, PEH was not observed at any time. PKA increased at 15min postexercise in the ND (P<0.05), but not in the T2D patients. CONCLUSION: T2D individuals have a lower PKA response to exercise, which probably suppresses its hypotensive effect, thus reinforcing the possible role of PKA on PEH.
Authors: Ricardo Yukio Asano; Marcelo Magalhães Sales; Rodrigo Alberto Vieira Browne; José Fernando Vila Nova Moraes; Hélio José Coelho Júnior; Milton Rocha Moraes; Herbert Gustavo Simões Journal: World J Diabetes Date: 2014-10-15
Authors: Marcelo M Sales; Carmen Sílvia G Campbell; Pâmella K Morais; Carlos Ernesto; Lúcio F Soares-Caldeira; Paulo Russo; Daisy F Motta; Sérgio R Moreira; Fábio Y Nakamura; Herbert G Simões Journal: Diabetol Metab Syndr Date: 2011-01-12 Impact factor: 3.320
Authors: Caio Victor de Sousa; Marcelo Magalhães Sales; Samuel da Silva Aguiar; Daniel Alexandre Boullosa; Thiago Dos Santos Rosa; Vilmar Baldissera; Herbert Gustavo Simões Journal: J Phys Ther Sci Date: 2016-06-28
Authors: Marcelo Magalhaes Sales; Caio Victor de Sousa; Wellington Barbosa Sampaio; Carlos Ernesto; Rodrigo Alberto Vieira Browne; Jose Fernando Vila Nova de Moraes; Daisy Motta-Santos; Milton Rocha Moraes; John Eugene Lewis; Herbert Gustavo Simões; Francisco Martins da Silva Journal: Asian J Sports Med Date: 2016-05-28
Authors: Luan M Azevêdo; Alice C de Souza; Laiza Ellen S Santos; Rodrigo Miguel Dos Santos; Manuella O M de Fernandes; Jeeser A Almeida; Emerson Pardono Journal: Front Cardiovasc Med Date: 2017-02-14