Literature DB >> 20577995

Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes.

Chantel D Campbell1, John C Vederas.   

Abstract

The fungal polyketide lovastatin is a cholesterol lowering agent that is an immediate precursor to a multi-billion dollar drug, simvastatin (Zocor). Lovastatin is produced by an iterative type I polyketide synthase known as LovB and a partner enoyl reductase (LovC). There is evidence that a Diels-Alderase enzyme activity is utilized in its biosynthesis. This review examines the biosynthesis of lovastatin, as well as of compactin, equisetin, cytochalasins, and solanapyrones, which are other structurally related polyketides that appear to utilize a Diels-Alderase. Copyright 2010 Wiley Periodicals, Inc.

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Year:  2010        PMID： 20577995     DOI： 10.1002/bip.21428

Source DB:  PubMed          Journal:  Biopolymers        ISSN： 0006-3525            Impact factor:   2.505


  35 in total

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