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Literature DB >> 20577697

Click-based synthesis and proteomic profiling of lipstatin analogues.

Mun H Ngai¹, Peng-Yu Yang, Kai Liu, Yuan Shen, Markus R Wenk, Shao Q Yao, Martin J Lear.

Abstract

Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.

Entities: Chemical Disease Gene

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Year: 2010 PMID： 20577697 DOI： 10.1039/c0cc01276a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

6 in total

1. Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.

Authors: Paul A Jackson; John C Widen; Daniel A Harki; Kay M Brummond
Journal: J Med Chem Date: 2016-12-20 Impact factor: 7.446

2. The 1,2,3-triazole derivative KP-A021 suppresses osteoclast differentiation and function by inhibiting RANKL-mediated MEK-ERK signaling pathway.

Authors: Hye Jung Ihn; Doohyun Lee; Taeho Lee; Hong-In Shin; Yong Chul Bae; Sang-Hyun Kim; Eui Kyun Park
Journal: Exp Biol Med (Maywood) Date: 2015-03-13

3. Targeting lipid esterases in mycobacteria grown under different physiological conditions using activity-based profiling with tetrahydrolipstatin (THL).

Authors: Madhu Sudhan Ravindran; Srinivasa P S Rao; Xiamin Cheng; Ankit Shukla; Amaury Cazenave-Gassiot; Shao Q Yao; Markus R Wenk
Journal: Mol Cell Proteomics Date: 2013-12-17 Impact factor: 5.911

Click-based synthesis and proteomic profiling of lipstatin analogues.

1. Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.

2. The 1,2,3-triazole derivative KP-A021 suppresses osteoclast differentiation and function by inhibiting RANKL-mediated MEK-ERK signaling pathway.

3. Targeting lipid esterases in mycobacteria grown under different physiological conditions using activity-based profiling with tetrahydrolipstatin (THL).

4. Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles.

5. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.

6. Separation of Alkyne Enantiomers by Chiral Column HPLC Analysis of Their Cobalt-Complexes.