| Literature DB >> 20577059 |
Abstract
Ghrelin and leptin, putative controllers of human appetite, have no effect on human meal-to-meal appetite but respond to variations in energy availability. Nonhomeostatic characteristics of appetite and spontaneous activity stem from inhibition by leptin and ghrelin of brain reward circuit that is responsive to energy deficit, but refractory in obesity, and from the operation of a meal-timing circadian clock.Entities:
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Year: 2010 PMID: 20577059 PMCID: PMC2943207 DOI: 10.1097/JES.0b013e3181e3728f
Source DB: PubMed Journal: Exerc Sport Sci Rev ISSN: 0091-6331 Impact factor: 6.230