BACKGROUND: Circulating antiendothelial cell antibodies (AECA) bind to endothelial antigens and induce endothelial cell damage. These antibodies have been detected in patients with collagen vascular diseases and systemic vasculitis. Recently, autoimmune mechanisms and vascular involvement have attracted attention in COPD. This study aimed to investigate the expression of AECA in patients with COPD. METHODS: A total of 116 patients with COPD, whose condition was established based on the Global Initiative for Chronic Obstructive Lung Disease criteria, were evaluated. Serum samples were examined for AECA by a cellular enzyme-linked immunosorbent assay using human umbilical vein endothelial cells. In addition, 157 subjects without any clinical or radiologic evidence of COPD or pulmonary disease served as a reference population. RESULTS: The patients with COPD exhibited significantly higher serum AECA concentrations than subjects in the reference population. The expression of AECA was significantly elevated in the patients with COPD, even when compared with that in smokers among the reference population who had similar smoking habits to the patients with COPD but normal spirometry. CONCLUSIONS: These findings suggest that an autoimmune component associated with endothelial cell damage is possibly involved in COPD.
BACKGROUND: Circulating antiendothelial cell antibodies (AECA) bind to endothelial antigens and induce endothelial cell damage. These antibodies have been detected in patients with collagen vascular diseases and systemic vasculitis. Recently, autoimmune mechanisms and vascular involvement have attracted attention in COPD. This study aimed to investigate the expression of AECA in patients with COPD. METHODS: A total of 116 patients with COPD, whose condition was established based on the Global Initiative for Chronic Obstructive Lung Disease criteria, were evaluated. Serum samples were examined for AECA by a cellular enzyme-linked immunosorbent assay using human umbilical vein endothelial cells. In addition, 157 subjects without any clinical or radiologic evidence of COPD or pulmonary disease served as a reference population. RESULTS: The patients with COPD exhibited significantly higher serum AECA concentrations than subjects in the reference population. The expression of AECA was significantly elevated in the patients with COPD, even when compared with that in smokers among the reference population who had similar smoking habits to the patients with COPD but normal spirometry. CONCLUSIONS: These findings suggest that an autoimmune component associated with endothelial cell damage is possibly involved in COPD.
Authors: Paul A Kirkham; Gaetano Caramori; Paolo Casolari; Alberto A Papi; Matt Edwards; Betty Shamji; Kostas Triantaphyllopoulos; Farhana Hussain; Mariona Pinart; Younis Khan; Lucy Heinemann; Laurie Stevens; Mike Yeadon; Peter J Barnes; Kian F Chung; Ian M Adcock Journal: Am J Respir Crit Care Med Date: 2011-10-01 Impact factor: 21.405
Authors: Corry-Anke Brandsma; Wim Timens; Marie Geerlings; Henrike Jekel; Dirkje S Postma; Machteld N Hylkema; Huib A M Kerstjens Journal: BMC Pulm Med Date: 2010-12-13 Impact factor: 3.317