Literature DB >> 20576296

Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism.

Mario Gonzalez-Gronow1, Miguel Cuchacovich, Rina Francos, Stephanie Cuchacovich, Maria del Pilar Fernandez, Angel Blanco, Edith V Bowers, Steven Kaczowka, Salvatore V Pizzo.   

Abstract

Autistic children show elevated serum levels of autoantibodies to several proteins essential for the function of normal brains. The voltage-dependent anion channel (VDAC) and hexokinase-I, a VDAC protective ligand, were identified as targets of this autoimmunity in autistic children. These autoantibodies were purified using immunoaffinity chromatographic techniques. Both antibodies induce apoptosis of cultured human neuroblastoma cells. Because VDAC and hexokinase-I are essential for brain protection from ischemic damage, the presence of these autoantibodies suggests a possible causal role in the neurologic pathogenesis of autism.
Copyright © 2010 Elsevier B.V. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20576296      PMCID： PMC2943043          DOI： 10.1016/j.jneuroim.2010.06.001

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  47 in total

Review 1.  New functions of an old protein: the eukaryotic porin or voltage dependent anion selective channel (VDAC).

Authors:  Vito De Pinto; Angela Messina; Rosita Accardi; Rita Aiello; Francesca Guarino; Marianna Flora Tomasello; Massimo Tommasino; Gianluca Tasco; Rita Casadio; Roland Benz; Francesca De Giorgi; François Ichas; Mark Baker; Alfons Lawen
Journal:  Ital J Biochem       Date:  2003-03

2.  The possible role of the cerebellum in autism/PDD: disruption of a multisensory feedback loop.

Authors:  J K Kern
Journal:  Med Hypotheses       Date:  2002-09       Impact factor: 1.538

3.  Functional glucokinase isoforms are expressed in rat brain.

Authors:  I Roncero; E Alvarez; P Vázquez; E Blázquez
Journal:  J Neurochem       Date:  2000-05       Impact factor: 5.372

Review 4.  The serotonin system in autism.

Authors:  E H Cook; B L Leventhal
Journal:  Curr Opin Pediatr       Date:  1996-08       Impact factor: 2.856

5.  Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A.

Authors:  A Vojdani; A W Campbell; E Anyanwu; A Kashanian; K Bock; E Vojdani
Journal:  J Neuroimmunol       Date:  2002-08       Impact factor: 3.478

Review 6.  Autism.

Authors:  Fred R Volkmar; David Pauls
Journal:  Lancet       Date:  2003-10-04       Impact factor: 79.321

7.  Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism.

Authors:  A Vojdani; J B Pangborn; E Vojdani; E L Cooper
Journal:  Int J Immunopathol Pharmacol       Date:  2003 Sep-Dec       Impact factor: 3.219

8.  One-step on-column affinity refolding purification and functional analysis of recombinant human VDAC1.

Authors:  Yong Shi; Chunsun Jiang; Quan Chen; Hong Tang
Journal:  Biochem Biophys Res Commun       Date:  2003-04-04       Impact factor: 3.575

9.  Anti-porin antibodies prevent excitotoxic and ischemic damage to brain tissue.

Authors:  Jose L Perez Velazquez; Larisa Kokarovtseva; Michael Weisspapir; Marina V Frantseva
Journal:  J Neurotrauma       Date:  2003-07       Impact factor: 5.269

10.  Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells.

Authors:  S Shimizu; Y Matsuoka; Y Shinohara; Y Yoneda; Y Tsujimoto
Journal:  J Cell Biol       Date:  2001-01-22       Impact factor: 10.539
View more
  12 in total

1.  Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.

Authors:  Chao-Jun Hu; Guang Song; Wei Huang; Guo-Zhen Liu; Chui-Wen Deng; Hai-Pan Zeng; Li Wang; Feng-Chun Zhang; Xuan Zhang; Jun Seop Jeong; Seth Blackshaw; Li-Zhi Jiang; Heng Zhu; Lin Wu; Yong-Zhe Li
Journal:  Mol Cell Proteomics       Date:  2012-05-30       Impact factor: 5.911

Review 2.  A mitochondrial bioenergetic basis of depression.

Authors:  N Jennifer Klinedinst; William T Regenold
Journal:  J Bioenerg Biomembr       Date:  2014-09-28       Impact factor: 2.945

3.  Peptide sharing between influenza A H1N1 hemagglutinin and human axon guidance proteins.

Authors:  Guglielmo Lucchese; Giovanni Capone; Darja Kanduc
Journal:  Schizophr Bull       Date:  2013-01-31       Impact factor: 9.306

4.  The voltage-dependent anion channel (VDAC) binds tissue-type plasminogen activator and promotes activation of plasminogen on the cell surface.

Authors:  Mario Gonzalez-Gronow; Rupa Ray; Fang Wang; Salvatore V Pizzo
Journal:  J Biol Chem       Date:  2012-11-16       Impact factor: 5.157

5.  Binding of tissue-type plasminogen activator to the glucose-regulated protein 78 (GRP78) modulates plasminogen activation and promotes human neuroblastoma cell proliferation in vitro.

Authors:  Mario Gonzalez-Gronow; Cristian Farias Gomez; Gustaaf G de Ridder; Rupa Ray; Salvatore V Pizzo
Journal:  J Biol Chem       Date:  2014-07-24       Impact factor: 5.157

6.  Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis.

Authors:  Gary L Norman; Chen-Yen Yang; Heather P Ostendorff; Zakera Shums; Mark J Lim; Jinjun Wang; Amany Awad; Gideon M Hirschfield; Piotr Milkiewicz; Donald B Bloch; Kenneth J Rothschild; Christopher L Bowlus; Iannis E Adamopoulos; Patrick S C Leung; Harry J Janssen; Angela C Cheung; Catalina Coltescu; M Eric Gershwin
Journal:  Liver Int       Date:  2014-10-10       Impact factor: 5.828

Review 7.  Plasma membrane coenzyme Q: evidence for a role in autism.

Authors:  Frederick L Crane; Hans Löw; Iris Sun; Placido Navas; Anna Gvozdjáková
Journal:  Biologics       Date:  2014-05-29

8.  Autoantibody Biomarker Discovery in Primary Open Angle Glaucoma Using Serological Proteome Analysis (SERPA).

Authors:  Vanessa M Beutgen; Natarajan Perumal; Norbert Pfeiffer; Franz H Grus
Journal:  Front Immunol       Date:  2019-03-07       Impact factor: 7.561

9.  HLA Immune Function Genes in Autism.

Authors:  Anthony R Torres; Jonna B Westover; Allen J Rosenspire
Journal:  Autism Res Treat       Date:  2012-02-15

10.  A Spectrum of Neural Autoantigens, Newly Identified by Histo-Immunoprecipitation, Mass Spectrometry, and Recombinant Cell-Based Indirect Immunofluorescence.

Authors:  Madeleine Scharf; Ramona Miske; Stephanie Kade; Stefanie Hahn; Yvonne Denno; Nora Begemann; Nadine Rochow; Christiane Radzimski; Stephanie Brakopp; Christian Probst; Bianca Teegen; Winfried Stöcker; Lars Komorowski
Journal:  Front Immunol       Date:  2018-07-09       Impact factor: 7.561
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.