OBJECTIVES: To investigate a possible association between the severity of lower urinary tract symptoms (LUTS) and the serum levels of sex hormones in men with symptomatic benign prostatic hyperplasia (BPH) that underwent surgery for severe benign prostatic obstruction. PATIENTS AND METHODS: In all, 127 selected men with symptomatic BPH attending our urology clinic were recruited. The clinical conditions of BPH were assessed by digital rectal examination, serum prostate-specific antigen (PSA) determination, International Prostate Symptom Score (IPSS), transrectal ultrasonography and maximum urinary flow rate (Q(max) ) value at uroflussimetry. Before surgery, we measured the serum concentrations of total testosterone (TT) and free testosterone (FT), oestradiol, prolactin, luteinizing hormone and follicle-stimulating hormone. We excluded men with endocrine diseases, those with prostate disease who were receiving antiandrogen therapy and those with psychological diseases. The relationships between the IPSS score and serum sex hormone levels were determined. RESULTS: The final study population consisted of 122 men (mean age of 70.66 years), as five were excluded (three due to incomplete evaluation and two who were diagnosed with prostate cancer). On statistical analysis, the total IPSS was significantly associated with age (r= 0.405, P < 0.001) and TT (r= 0.298, P= 0.020) but not with FT or the serum levels of the other sex hormones. The serum levels of testosterone and IPSS did not correlate with prostate volume and Q(max) . PSA level and age correlated with prostate volume (r= 0.394, P < 0.001; r = 0.374, P < 0.001, respectively). We distinguished two subgroups of patients: the first group of 40 men with an IPSS of <19 and the second group of 82 with an IPSS of >19, and we evaluated the median levels of TT in each group. There was an increased risk of LUTS in men with a greater serum concentration of TT (P= 0.042), although the mean TT level was in the normal range. CONCLUSIONS: In the present study, the severity of LUTS was associated with age and serum levels of TT but only age correlated with the measures of BPH, especially prostate volume. The potential effects of testosterone on LUTS may well be indirect. Additional large studies are needed to confirm these preliminary results.
OBJECTIVES: To investigate a possible association between the severity of lower urinary tract symptoms (LUTS) and the serum levels of sex hormones in men with symptomatic benign prostatic hyperplasia (BPH) that underwent surgery for severe benign prostatic obstruction. PATIENTS AND METHODS: In all, 127 selected men with symptomatic BPH attending our urology clinic were recruited. The clinical conditions of BPH were assessed by digital rectal examination, serum prostate-specific antigen (PSA) determination, International Prostate Symptom Score (IPSS), transrectal ultrasonography and maximum urinary flow rate (Q(max) ) value at uroflussimetry. Before surgery, we measured the serum concentrations of total testosterone (TT) and free testosterone (FT), oestradiol, prolactin, luteinizing hormone and follicle-stimulating hormone. We excluded men with endocrine diseases, those with prostate disease who were receiving antiandrogen therapy and those with psychological diseases. The relationships between the IPSS score and serum sex hormone levels were determined. RESULTS: The final study population consisted of 122 men (mean age of 70.66 years), as five were excluded (three due to incomplete evaluation and two who were diagnosed with prostate cancer). On statistical analysis, the total IPSS was significantly associated with age (r= 0.405, P < 0.001) and TT (r= 0.298, P= 0.020) but not with FT or the serum levels of the other sex hormones. The serum levels of testosterone and IPSS did not correlate with prostate volume and Q(max) . PSA level and age correlated with prostate volume (r= 0.394, P < 0.001; r = 0.374, P < 0.001, respectively). We distinguished two subgroups of patients: the first group of 40 men with an IPSS of <19 and the second group of 82 with an IPSS of >19, and we evaluated the median levels of TT in each group. There was an increased risk of LUTS in men with a greater serum concentration of TT (P= 0.042), although the mean TT level was in the normal range. CONCLUSIONS: In the present study, the severity of LUTS was associated with age and serum levels of TT but only age correlated with the measures of BPH, especially prostate volume. The potential effects of testosterone on LUTS may well be indirect. Additional large studies are needed to confirm these preliminary results.
Authors: V Favilla; S Cimino; C Salamone; E Fragalà; M Madonia; R Condorelli; S La Vignera; L Mongioì; F Pirozzi Farina; G I Russo; G Morgia Journal: J Endocrinol Invest Date: 2013-12 Impact factor: 4.256
Authors: Giorgio Ivan Russo; Sebastiano Cimino; Eugenia Fragalà; Salvatore Privitera; Sandro La Vignera; Rosita Condorelli; Aldo E Calogero; Mario Chisari; Tommaso Castelli; Vincenzo Favilla; Giuseppe Morgia Journal: World J Urol Date: 2014-09-05 Impact factor: 4.226
Authors: I A Korneyev; T A Alexeeva; S H Al-Shukri; A N Bernikov; A A Erkovich; A A Kamalov; M I Kogan; V N Pavlov; V N Zhuravlev; D Y Pushkar Journal: Int J Impot Res Date: 2016-02-11 Impact factor: 2.896
Authors: Dong Soo Park; Jong Jin Oh; Jae Yup Hong; Young Kwon Hong; Don Kyung Choi; In Hyuck Gong; Jin Ho Hwang; Sung Won Kwon Journal: Asian J Androl Date: 2013-01-28 Impact factor: 3.285
Authors: V Favilla; G I Russo; G Reale; S Leone; T Castelli; S La Vignera; R A Condorelli; A E Calogero; S Cimino; G Morgia Journal: Int J Impot Res Date: 2015-07-30 Impact factor: 2.896
Authors: Aleksandra Rył; Iwona Rotter; Tomasz Miazgowski; Marcin Słojewski; Barbara Dołęgowska; Anna Lubkowska; Maria Laszczyńska Journal: Diabetol Metab Syndr Date: 2015-10-29 Impact factor: 3.320
Authors: M Kirby; C Chapple; G Jackson; I Eardley; D Edwards; G Hackett; D Ralph; J Rees; M Speakman; J Spinks; K Wylie Journal: Int J Clin Pract Date: 2013-04-25 Impact factor: 2.503