Literature DB >> 20574802

Tranexamic acid reduces allogenic transfusion in revision hip arthroplasty.

Shahryar Noordin1, Terrence S Waters, Donald S Garbuz, Clive P Duncan, Bassam A Masri.   

Abstract

BACKGROUND: Revision THA is associated with high blood loss and a high probability of blood transfusion in the perioperative period. In November 2003, government legislation established the Blood Utilization Program at our center to reduce the rate and risks associated with allogenic transfusion. QUESTIONS/PURPOSES: The purposes of this study were to (1) determine whether the allogenic transfusion rate in patients undergoing revision THA decreased in those who were reviewed preoperatively by the Blood Utilization Program versus those who were not; (2) determine whether tranexamic acid reduced the rate of transfusion; and (3) identify potential perioperative clinical parameters that are associated with an increased risk of blood transfusion.
METHODS: We included all 159 patients who underwent revision THA from January 2006 to October 2008 having either a socket and/or femoral stem revision except those having only a liner exchange. One hundred and one patients attended the Blood Utilization Program preoperatively and 58 patients did not (ie, they required urgent/emergency surgery).
RESULTS: The Blood Utilization Program referral made no difference in transfusion rate or transfusion amount; however, the transfusion rates and amount were decreased by 8% and one unit, respectively. In patients referred to the Blood Utilization Program, the intraoperative use of tranexamic acid (an antifibrinolytic) was associated with reduced transfusions, regardless of dosage; preoperative erythropoietin tended to reduce transfusions while preoperative oral iron supplements did not.
CONCLUSIONS: To further increase the relevance of the blood utilization program, the guidelines for patients undergoing revision hip arthroplasty need to be redefined. LEVEL OF EVIDENCE: Level III, therapeutic study. See the guidelines online for a complete description of level of evidence.

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Year:  2011        PMID: 20574802      PMCID: PMC3018213          DOI: 10.1007/s11999-010-1441-2

Source DB:  PubMed          Journal:  Clin Orthop Relat Res        ISSN: 0009-921X            Impact factor:   4.176


  29 in total

1.  Erythropoietin and preoperative autologous blood donation in the prevention of hepatitis C infection: necessity or luxury?

Authors:  M C Woronoff-Lemsi; P Arveux; S Limat; P Morel; C Le Pen; J Y Cahn
Journal:  Transfusion       Date:  1999-09       Impact factor: 3.157

2.  Preoperative hemoglobin levels and the need for transfusion after prosthetic hip and knee surgery: analysis of predictive factors.

Authors:  Jose A Salido; Luis A Marín; Luis A Gómez; Pedro Zorrilla; Cristóbal Martínez
Journal:  J Bone Joint Surg Am       Date:  2002-02       Impact factor: 5.284

3.  Comparison of hypotensive epidural anaesthesia and spinal anaesthesia on blood loss and coagulation during and after total hip arthroplasty.

Authors:  T T Niemi; M Pitkänen; M Syrjälä; P H Rosenberg
Journal:  Acta Anaesthesiol Scand       Date:  2000-04       Impact factor: 2.105

4.  A prospective, randomized study of preoperative autologous donation for hip replacement surgery.

Authors:  Dinna B Billote; Silas N Glisson; David Green; Richard L Wixson
Journal:  J Bone Joint Surg Am       Date:  2002-08       Impact factor: 5.284

5.  Predicting allogeneic blood transfusion use in total joint arthroplasty.

Authors:  Saifudin Rashiq; Meera Shah; Ava K Chow; Paul J O'Connor; Barry A Finegan
Journal:  Anesth Analg       Date:  2004-10       Impact factor: 5.108

6.  Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis.

Authors:  Gary E Hill; William H Frawley; Karl E Griffith; John E Forestner; Joseph P Minei
Journal:  J Trauma       Date:  2003-05

7.  Tranexamic acid reduces blood loss and blood transfusions in primary total hip arthroplasty: a prospective randomized double-blind study in 40 patients.

Authors:  Henrik Husted; Lars Blønd; Stig Sonne-Holm; Gitte Holm; Tine W Jacobsen; Peter Gebuhr
Journal:  Acta Orthop Scand       Date:  2003-12

8.  Efficacy of intraoperative blood collection and reinfusion in revision total hip arthroplasty.

Authors:  Jeffrey Zarin; David Grosvenor; David Schurman; Stuart Goodman
Journal:  J Bone Joint Surg Am       Date:  2003-11       Impact factor: 5.284

9.  Use of intravenous tranexamic acid to reduce allogeneic blood transfusion in total hip and knee arthroplasty: a meta-analysis.

Authors:  K M Ho; H Ismail
Journal:  Anaesth Intensive Care       Date:  2003-10       Impact factor: 1.669

10.  The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement.

Authors:  K Rajesparan; L C Biant; M Ahmad; R E Field
Journal:  J Bone Joint Surg Br       Date:  2009-06
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  13 in total

1.  Topical tranexamic acid reduces blood loss and transfusion rates associated with primary total hip arthroplasty.

Authors:  Chih-Hsiang Chang; Yuhan Chang; Dave W Chen; Steve W N Ueng; Mel S Lee
Journal:  Clin Orthop Relat Res       Date:  2014-01-03       Impact factor: 4.176

2.  Does Tranexamic Acid Reduce Bleeding during Femoral Fracture Operation?

Authors:  Mohammad Haghighi; Hossein Ettehad; Mohsen Mardani-Kivi; Ahmadreza Mirbolook; Bahram Naderi Nabi; Roya Moghaddam; Abbas Sedighinejad; Gita Khanjanian
Journal:  Arch Bone Jt Surg       Date:  2017-03

3.  The role of intraoperative cell salvage system on blood management in major orthopedic surgeries: a cost-benefit analysis.

Authors:  Altuğ Duramaz; Mustafa Gökhan Bilgili; Berhan Bayram; Nezih Ziroğlu; Erdem Edipoğlu; Halil Nadir Öneş; Cemal Kural; Mustafa Cevdet Avkan
Journal:  Eur J Orthop Surg Traumatol       Date:  2017-12-06

4.  Use of Topical Tranexamic Acid Reduces Direct and Indirect Blood Loss and Transfusion Rates in Revision Total Hip Arthroplasty.

Authors:  Elina Huerfano; Manuel Huerfano; Kate Shanaghan; Maureen Barlow; Stavros Memtsoudis; Alejandro Gonzalez Della Valle
Journal:  HSS J       Date:  2019-10-18

5.  The Use of Preoperative Epoetin-α in Revision Hip Arthroplasty.

Authors:  Lawrence A Delasotta; Ashwin Rangavajjula; Michael L Frank; Jamie Blair; Fabio Orozco; Alvin Ong
Journal:  Open Orthop J       Date:  2012-05-11

Review 6.  Management of Blood Loss in Hip Arthroplasty: Korean Hip Society Current Consensus.

Authors:  Joo-Hyoun Song; Jang Won Park; Young-Kyun Lee; In-Sung Kim; Jae-Hwi Nho; Kyung-Jae Lee; Kwan Kyu Park; Yeesuk Kim; Jai Hyung Park; Seung Beom Han
Journal:  Hip Pelvis       Date:  2017-06-02

7.  Intraoperative blood loss as indicated by haemoglobin trend is a predictor for the development of postoperative spinal implant infection-a matched-pair analysis.

Authors:  Friederike Schömig; Justus Bürger; Zhouyang Hu; Axel Pruß; Edda Klotz; Matthias Pumberger; Christian Hipfl
Journal:  J Orthop Surg Res       Date:  2021-06-18       Impact factor: 2.359

8.  Revision Total Hip Arthroplasty in Jehovah's Witnesses at a Public Hospital: Practical Recommendations for a Low-Resource Setting.

Authors:  Marlon M Mencia; Allan Beharry; Pedro P Hernandez Cruz
Journal:  Cureus       Date:  2021-06-19

9.  Comparison of Pre- and Postoperative Hemoglobin and Hematocrit Levels in Hip Arthroscopy.

Authors:  Roberto Seijas; Wenceslao Espinosa; Andrea Sallent; Xavier Cuscó; Ramón Cugat; Oscar Ares
Journal:  Open Orthop J       Date:  2015-08-31

10.  Intravenous tranexamic acid use in revision total joint arthroplasty: a meta-analysis.

Authors:  Feng-Chih Kuo; Pao-Yen Lin; Jun-Wen Wang; Po-Chun Lin; Mel S Lee; Antonia F Chen
Journal:  Drug Des Devel Ther       Date:  2018-09-24       Impact factor: 4.162

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