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Literature DB >> 20574723

Magnetic biosensor technologies for medical applications: a review.

J Llandro¹, J J Palfreyman, A Ionescu, C H W Barnes.

Abstract

In this review we discuss conventional methods of performing biological assays and molecular identification and highlight their advantages and limitations. An alternative approach based on magnetic nanotechnology is then presented. Firstly, magnetic carriers are introduced and their biocompatibility and functionalisation discussed, with spotlights on functionalisation via self assembled monolayers and on methods of reducing nonspecific binding. In addition an introduction is provided to the basic physical concepts behind the various types of sensors used to detect magnetic labels. Finally, progress in the field of magnetic biosensors and the outlook for the future are discussed.

Mesh：

Substances：
Magnetite Nanoparticles

Year: 2010 PMID： 20574723 DOI： 10.1007/s11517-010-0649-3

Source DB: PubMed Journal: Med Biol Eng Comput ISSN： 0140-0118 Impact factor: 2.602

75 in total

1. In situ localized amplification and contact replication of many individual DNA molecules.

Authors: R D Mitra; G M Church
Journal: Nucleic Acids Res Date: 1999-12-15 Impact factor: 16.971

2. Submicrometer metallic barcodes.

Authors: S R Nicewarner-Pena; R G Freeman; B D Reiss; L He; D J Pena; I D Walton; R Cromer; C D Keating; M J Natan
Journal: Science Date: 2001-10-05 Impact factor: 47.728

3. High sensitivity detection of molecular recognition using magnetically labelled biomolecules and magnetoresistive sensors.

Authors: D L Graham; H A Ferreira; P P Freitas; J M S Cabral
Journal: Biosens Bioelectron Date: 2003-04 Impact factor: 10.618

4. Comparison of a prototype magnetoresistive biosensor to standard fluorescent DNA detection.

Authors: J Schotter; P B Kamp; A Becker; A Pühler; G Reiss; H Brückl
Journal: Biosens Bioelectron Date: 2004-05-15 Impact factor: 10.618

5. An integrated microfluidic biochemical detection system for protein analysis with magnetic bead-based sampling capabilities.

Authors: Jin-Woo Choi; Kwang W Oh; Jennifer H Thomas; William R Heineman; H Brian Halsall; Joseph H Nevin; Arthur J Helmicki; H Thurman Henderson; Chong H Ahn
Journal: Lab Chip Date: 2001-12-06 Impact factor: 6.799

6. Surface modification of magnetic nanoparticles capped by oleic acids: characterization and colloidal stability in polar solvents.

Authors: Sang-Yup Lee; Michael T Harris
Journal: J Colloid Interface Sci Date: 2005-07-28 Impact factor: 8.128

Magnetic biosensor technologies for medical applications: a review.

1. In situ localized amplification and contact replication of many individual DNA molecules.

2. Submicrometer metallic barcodes.

3. High sensitivity detection of molecular recognition using magnetically labelled biomolecules and magnetoresistive sensors.

4. Comparison of a prototype magnetoresistive biosensor to standard fluorescent DNA detection.

5. An integrated microfluidic biochemical detection system for protein analysis with magnetic bead-based sampling capabilities.

6. Surface modification of magnetic nanoparticles capped by oleic acids: characterization and colloidal stability in polar solvents.

7. Formation of dense self-assembled monolayers of (n-decyl)trichlorosilanes on Ta/Ta2O5.

8. Multistep synthesis on SU-8: combining microfabrication and solid-phase chemistry on a single material.

9. Synthesis of ultrasmall magnetic iron oxide nanoparticles and study of their colloid and surface chemistry.

10. Matrix-insensitive protein assays push the limits of biosensors in medicine.

1. Multifunctional magnetic rotator for micro and nanorheological studies.

2. Micro and nanotechnology for biological and biomedical applications.

3. Vinamax: a macrospin simulation tool for magnetic nanoparticles.

4. Magnetic particles in ultrasensitive biomarker protein measurements for cancer detection and monitoring.

5. Biosensor diagnosis of urinary tract infections: a path to better treatment?

Review 6. Microchip-based detection of magnetically labeled cancer biomarkers.

7. A quantitative study of nanoparticle skin penetration with interactive segmentation.

8. The Scanning TMR Microscope for Biosensor Applications.

9. A Novel SNPs Detection Method Based on Gold Magnetic Nanoparticles Array and Single Base Extension.

10. Highly sensitive and rapid detection of Pseudomonas aeruginosa based on magnetic enrichment and magnetic separation.