Literature DB >> 20573507

Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives.

Kazutaka Nakamoto1, Itaru Tsukada, Keigo Tanaka, Masayuki Matsukura, Toru Haneda, Satoshi Inoue, Norio Murai, Shinya Abe, Norihiro Ueda, Mamiko Miyazaki, Naoaki Watanabe, Makoto Asada, Kentaro Yoshimatsu, Katsura Hata.   

Abstract

Quinoline amide, azaindole amide and pyridine amides were synthesized and tested for in vitro antifungal activity against fungi. These synthesized amides have potent antifungal activity against Candida albicans and Aspergillus fumigatus. Our results suggest that hetero ring amides may be potent antifungal agents that operate by inhibiting the function of Gwt1 protein in the GPI biosynthetic pathway. Copyright 2010 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20573507     DOI： 10.1016/j.bmcl.2010.06.005

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis.

Authors:  Nao-Aki Watanabe; Mamiko Miyazaki; Takaaki Horii; Koji Sagane; Kappei Tsukahara; Katsura Hata
Journal:  Antimicrob Agents Chemother       Date:  2011-12-05       Impact factor: 5.191

2.  Analysis of membrane topology and identification of essential residues for the yeast endoplasmic reticulum inositol acyltransferase Gwt1p.

Authors:  Koji Sagane; Mariko Umemura; Kaoru Ogawa-Mitsuhashi; Kappei Tsukahara; Takehiko Yoko-o; Yoshifumi Jigami
Journal:  J Biol Chem       Date:  2011-03-02       Impact factor: 5.157

3.  In vitro activity of E1210, a novel antifungal, against clinically important yeasts and molds.

Authors:  Mamiko Miyazaki; Takaaki Horii; Katsura Hata; Nao-Aki Watanabe; Kazutaka Nakamoto; Keigo Tanaka; Syuji Shirotori; Norio Murai; Satoshi Inoue; Masayuki Matsukura; Shinya Abe; Kentaro Yoshimatsu; Makoto Asada
Journal:  Antimicrob Agents Chemother       Date:  2011-08-08       Impact factor: 5.191

4.  Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis.

Authors:  Katsura Hata; Takaaki Horii; Mamiko Miyazaki; Nao-Aki Watanabe; Miyuki Okubo; Jiro Sonoda; Kazutaka Nakamoto; Keigo Tanaka; Syuji Shirotori; Norio Murai; Satoshi Inoue; Masayuki Matsukura; Shinya Abe; Kentaro Yoshimatsu; Makoto Asada
Journal:  Antimicrob Agents Chemother       Date:  2011-07-25       Impact factor: 5.191

Review 5.  Targeting the GPI biosynthetic pathway.

Authors:  Usha Yadav; Mohd Ashraf Khan
Journal:  Pathog Glob Health       Date:  2018-02-27       Impact factor: 2.894

6.  Synthesis of analogs of the Gwt1 inhibitor manogepix (APX001A) and in vitro evaluation against Cryptococcus spp.

Authors:  Michael Trzoss; Jonathan A Covel; Mili Kapoor; Molly K Moloney; Quinlyn A Soltow; Peter J Webb; Karen Joy Shaw
Journal:  Bioorg Med Chem Lett       Date:  2019-10-14       Impact factor: 2.823

7.  Chemogenomic Profiling of the Fungal Pathogen Candida albicans.

Authors:  Yaolin Chen; Jaideep Mallick; Alaa Maqnas; Yuan Sun; Baharul I Choudhury; Pierre Côte; Lan Yan; Ting-Jun-Hong Ni; Yan Li; Dazhi Zhang; Roberto Rodríguez-Ortiz; Quan-Zhen Lv; Yuan-Ying Jiang; Malcolm Whiteway
Journal:  Antimicrob Agents Chemother       Date:  2018-01-25       Impact factor: 5.191

8.  Microwave-assisted synthesis of new substituted anilides of quinaldic acid.

Authors:  Pavel Bobal; Josef Sujan; Jan Otevrel; Ales Imramovsky; Zdenka Padelkova; Josef Jampilek
Journal:  Molecules       Date:  2012-01-31       Impact factor: 4.411

9.  Microwave-Assisted Synthesis, Structural Characterization and Assessment of the Antibacterial Activity of Some New Aminopyridine, Pyrrolidine, Piperidine and Morpholine Acetamides.

Authors:  Abdulmajeed S H Alsamarrai; Saba S Abdulghani
Journal:  Molecules       Date:  2021-01-20       Impact factor: 4.411

10.  Aminopyrifen, a novel 2-aminonicotinate fungicide with a unique effect and broad-spectrum activity against plant pathogenic fungi.

Authors:  Masahiro Hatamoto; Ryo Aizawa; Kogomi Koda; Toshiki Fukuchi
Journal:  J Pestic Sci       Date:  2021-05-20       Impact factor: 2.529
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.