Literature DB >> 20573426

Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(omega-hydroxyalkylamino)-2(5H)-furanones.

Edyta Gondela1, Krzysztof Z Walczak.   

Abstract

5-(Omega-hydroxyalkylamino) derivatives of mucochloric acids were synthesized through a facile substitution reaction of 3,4-dichloro-5-hydroxy-2(5H)-furanone (mucochloric acid) acetate or 5-methylcarbonate with an appropriate amino alcohol or aminodiol. The obtained products were characterized and screened for their antibacterial and antiprotozoal activities. 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20573426     DOI： 10.1016/j.ejmech.2010.05.055

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  6 in total

1.  Synthesis of dihydrofuran-3-one and 9,10-phenanthrenequinone hybrid molecules and biological evaluation against colon cancer cells as selective Akt kinase inhibitors.

Authors:  Jingjing Huang; Yufei Chen; Yinfeng Guo; Ming Bao; Kemiao Hong; Yuanqing Zhang; Wenhao Hu; Jinping Lei; Yongqiang Liu; Xinfang Xu
Journal:  Mol Divers       Date:  2022-06-25       Impact factor: 2.943

2.  An efficient and facile synthesis of 3-amino-5-chromenyl-butenolides from 3-formyl chromone, dialkyl acetylenedicarboxylate, and primary amines.

Authors:  Saeed Balalaie; Morteza Ashouriha; Frank Rominger; Hamid Reza Bijanzadeh
Journal:  Mol Divers       Date:  2013-01-23       Impact factor: 2.943

3.  (1S,2R,4S)-1-[(Benzyl-amino)-meth-yl]-4-(prop-1-en-2-yl)cyclo-hexane-1,2-diol.

Authors:  Rachid Outouch; Brahim Boualy; Mustapha Ait Ali; Larbi El Firdoussi; Corrado Rizzoli
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-12-18

4.  (S)-3-Bromo-4-diallyl-amino-5-[(1R,2S,5R)-2-isopropyl-5-methyl-cyclo-hex-yloxy]furan-2(5H)-one.

Authors:  Jian-Hua Fu; Zhao-Yang Wang; Jian-Xiao Li; Yue-He Tan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-11-24

5.  (5S)-3-Chloro-4-diallyl-amino-5-[(1R,2S,5R)-2-isopropyl-5-methyl-cyclo-hex-yloxy]furan-2(5H)-one.

Authors:  Dong-Na Huang; Yue-He Tan; Jian-Hua Fu; Zhao-Yang Wang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-07-16

6.  Unraveling the Molecular Mechanism of Selective Antimicrobial Activity of 2(5H)-Furanone Derivative against Staphylococcus aureus.

Authors:  Irshad S Sharafutdinov; Anna S Pavlova; Farida S Akhatova; Alsu M Khabibrakhmanova; Elvira V Rozhina; Yulia J Romanova; Rawil Fakhrullin; Olga A Lodochnikova; Almira R Kurbangalieva; Mikhail I Bogachev; Airat R Kayumov
Journal:  Int J Mol Sci       Date:  2019-02-06       Impact factor: 5.923
  6 in total

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