Literature DB >> 20572190

Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action.

José Garcia1, Sofia Barluenga, Kristin Beebe, Len Neckers, Nicolas Winssinger.   

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Year:  2010        PMID： 20572190      PMCID： PMC7556733          DOI： 10.1002/chem.201001080

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


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  39 in total

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3.  Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa.

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Review 4.  Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update.

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Journal:  Expert Opin Emerg Drugs       Date:  2005-02       Impact factor: 4.191

Review 5.  Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.

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Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530

6.  Inhibition of HSP90 with pochoximes: SAR and structure-based insights.

Authors:  Sofia Barluenga; Jean-Gonzague Fontaine; Cuihua Wang; Kais Aouadi; Ruihong Chen; Kristin Beebe; Len Neckers; Nicolas Winssinger
Journal:  Chembiochem       Date:  2009-11-23       Impact factor: 3.164

7.  Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.

Authors:  John W Rice; James M Veal; R Patrick Fadden; Amy F Barabasz; Jeffrey M Partridge; Thomas E Barta; Laura G Dubois; Kenneth H Huang; Sarah R Mabbett; Melanie A Silinski; Paul M Steed; Steven E Hall
Journal:  Arthritis Rheum       Date:  2008-12

8.  Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase.

Authors:  C Gerhäuser; W Mar; S K Lee; N Suh; Y Luo; J Kosmeder; L Luyengi; H H Fong; A D Kinghorn; R M Moriarty
Journal:  Nat Med       Date:  1995-03       Impact factor: 53.440

Review 9.  Discovery and development of heat shock protein 90 inhibitors.

Authors:  Tony Taldone; Weilin Sun; Gabriela Chiosis
Journal:  Bioorg Med Chem       Date:  2008-11-06       Impact factor: 3.641

10.  Development of a fluorescence polarization assay for the molecular chaperone Hsp90.

Authors:  Joungnam Kim; Sara Felts; Laura Llauger; Huazhong He; Henri Huezo; Neal Rosen; Gabriela Chiosis
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  4 in total

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2.  Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology.

Authors:  John M Ketcham; Ivan Volchkov; Te-Yu Chen; Peter M Blumberg; Noemi Kedei; Nancy E Lewin; Michael J Krische
Journal:  J Am Chem Soc       Date:  2016-09-27       Impact factor: 15.419

3.  A Concise Enantioselective Synthesis and Cytotoxic Evaluation of the Anticancer Rotenoid Deguelin Enabled by a Tandem Knoevenagel/Conjugate Addition/Decarboxylation Sequence.

Authors:  Rebecca L Farmer; Karl A Scheidt
Journal:  Chem Sci       Date:  2013-08       Impact factor: 9.825

4.  Stereocontrolled semi-syntheses of deguelin and tephrosin.

Authors:  David A Russell; Julien J Freudenreich; Joe J Ciardiello; Hannah F Sore; David R Spring
Journal:  Org Biomol Chem       Date:  2017-01-30       Impact factor: 3.876
  4 in total

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