Literature DB >> 20571925

Juglanone, a novel α-tetralonyl derivative with potent antioxidant activity from Juglans mandshurica.

Lijuan Liu1, Wei Li, Tatsunori Sasaki, Yoshihisa Asada, Kazuo Koike.   

Abstract

A novel alpha-tetralonyl derivative, juglanone, was isolated from the fresh unripe fruits of Juglans mandshurica. Its structure was determined by spectroscopic analyses and from chemical evidence. Juglanone exhibited significant antioxidant activity in assays for 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and superoxide dismutase-like activity with IC(50) values of 10.1 and 9.0 microM, respectively. It also showed moderate cytotoxic activity against HL-60 human myeloid leukemia with an IC(50) value of 19.7 microM.

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Year:  2010        PMID： 20571925     DOI： 10.1007/s11418-010-0435-4

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


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