PURPOSE OF REVIEW: The review will integrate current knowledge of transcriptional circuits whose dysregulation leads to autoimmunity, neutropenia and leukemia. RECENT FINDINGS: Growth factor independent-1 (Gfi1) is a transcriptional repressor with essential roles in controlling hematopoietic stem cell biology, myeloid and lymphoid differentiation and lymphocyte effector functions. Recent work has suggested that Gfi1 competes or collaborates with other transcription factors to modulate transcription programs and lineage decisions. SUMMARY: Gfi1 is central to several transcriptional circuits whose dysregulation leads to abnormal or malignant hematopoiesis. These functional relationships are conserved from Drosophila development. Such conserved pathways represent central oncogenic or 'gatekeeper' pathways that are pivotal to understanding the process of cellular transformation, and illustrate key targets for clinical intervention.
PURPOSE OF REVIEW: The review will integrate current knowledge of transcriptional circuits whose dysregulation leads to autoimmunity, neutropenia and leukemia. RECENT FINDINGS:Growth factor independent-1 (Gfi1) is a transcriptional repressor with essential roles in controlling hematopoietic stem cell biology, myeloid and lymphoid differentiation and lymphocyte effector functions. Recent work has suggested that Gfi1 competes or collaborates with other transcription factors to modulate transcription programs and lineage decisions. SUMMARY:Gfi1 is central to several transcriptional circuits whose dysregulation leads to abnormal or malignant hematopoiesis. These functional relationships are conserved from Drosophila development. Such conserved pathways represent central oncogenic or 'gatekeeper' pathways that are pivotal to understanding the process of cellular transformation, and illustrate key targets for clinical intervention.
Authors: Jessica C Hochberg; Patricia M Miron; Beverly N Hay; Bruce A Woda; Sa A Wang; Monika Richert-Przygonska; Andrew A G Aprikyan; Peter E Newburger Journal: Pediatr Blood Cancer Date: 2008-03 Impact factor: 3.167
Authors: Shane R Horman; Chinavenmeni S Velu; Aditya Chaubey; Tristan Bourdeau; Jinfang Zhu; William E Paul; Brian Gebelein; H Leighton Grimes Journal: Blood Date: 2009-04-03 Impact factor: 22.113
Authors: Baotong Xie; Mark Charlton-Perkins; Elizabeth McDonald; Brian Gebelein; Tiffany Cook Journal: Development Date: 2007-10-31 Impact factor: 6.868
Authors: Jurgen A F Marteijn; Laurens T van der Meer; Liesbeth van Emst; Simon van Reijmersdal; Willemijn Wissink; Theo de Witte; Joop H Jansen; Bert A Van der Reijden Journal: Blood Date: 2007-07-23 Impact factor: 22.113
Authors: Nicholas A Watkins; Arief Gusnanto; Bernard de Bono; Subhajyoti De; Diego Miranda-Saavedra; Debbie L Hardie; Will G J Angenent; Antony P Attwood; Peter D Ellis; Wendy Erber; Nicola S Foad; Stephen F Garner; Clare M Isacke; Jennifer Jolley; Kerstin Koch; Iain C Macaulay; Sarah L Morley; Augusto Rendon; Kate M Rice; Niall Taylor; Daphne C Thijssen-Timmer; Marloes R Tijssen; C Ellen van der Schoot; Lorenz Wernisch; Thilo Winzer; Frank Dudbridge; Christopher D Buckley; Cordelia F Langford; Sarah Teichmann; Berthold Göttgens; Willem H Ouwehand Journal: Blood Date: 2009-02-19 Impact factor: 22.113
Authors: Michael G Daniel; David Sachs; Jeffrey M Bernitz; Yesai Fstkchyan; Katrina Rapp; Namita Satija; Kenneth Law; Foram Patel; Andreia M Gomes; Huen-Suk Kim; Carlos-Filipe Pereira; Benjamin Chen; Ihor R Lemischka; Kateri A Moore Journal: FEBS Lett Date: 2019-10-12 Impact factor: 4.124
Authors: Anna E Marneth; Lacramioara Botezatu; Judith M Hönes; Jimmy C L Israël; Judith Schütte; Lothar Vassen; Robert F Lams; Saskia M Bergevoet; Laura Groothuis; Amit Mandoli; Joost H A Martens; Gerwin Huls; Joop H Jansen; Ulrich Dührsen; Tobias Berg; Tarik Möröy; Christian Wichmann; Mia-Chia Lo; Dong-Er Zhang; Bert A van der Reijden; Cyrus Khandanpour Journal: Haematologica Date: 2018-04-19 Impact factor: 9.941
Authors: Gregory E Miller; Ann E Borders; Amy H Crockett; Kharah M Ross; Sameen Qadir; Lauren Keenan-Devlin; Adam K Leigh; Paula Ham; Jeffrey Ma; Jesusa M G Arevalo; Linda M Ernst; Steve W Cole Journal: Brain Behav Immun Date: 2017-04-21 Impact factor: 7.217
Authors: Daniel Andrade; Matthew Velinder; Jason Singer; Luke Maese; Diana Bareyan; Hong Nguyen; Mahesh B Chandrasekharan; Helena Lucente; David McClellan; David Jones; Sunil Sharma; Fang Liu; Michael E Engel Journal: Mol Cell Biol Date: 2016-05-02 Impact factor: 4.272