OBJECTIVE: The aim of this study was to investigate the survival of Lithuanian patients with Wegener's granulomatosis, who were followed up at two tertiary rheumatology centers, and to find the factors possibly influencing the outcomes of this disease. MATERIAL AND METHODS: Thirty-five patients were followed up prospectively from the onset of disease (the first patient was enrolled in 1994) at Vilnius University Hospital and the Center of Rheumatology of Kaunas University of Medicine (17 and 18 patients, respectively). All patients in both the centers were followed up on a routine basis, and their records contained necessary information about laboratory and biopsy data; the censoring date (end of follow-up) was stated in June 2006. RESULTS: Among the patients, the most frequent organs involved were ear, nose, throat (ENT) (82.6%), lungs (74.3%), and kidney (renal involvement was defined by proteinuria/abnormal urine sediment) (45.7%). Renal insufficiency was present in 20.6% of all the patients. At the end of the study, 32.4% of patients had simultaneously all three organ systems involved, namely upper respiratory tract, pulmonary, and renal. ANCA positivity was found for 26 (74.3%) of all the patients. Overall mortality rate was 25.7% (9/35). The mean survival was 99.4 months (95% CI, 73.6; 125.3) limited to 149 months for the longest-surviving patient. CONCLUSIONS: Female gender and all three specific organ involvements being present at the same time and higher vasculitis damage index were associated with poor outcome. Overall mortality rate was 25.7% (9/35) during the 12-year follow-up, and it is similar to the data from other European countries.
OBJECTIVE: The aim of this study was to investigate the survival of Lithuanian patients with Wegener's granulomatosis, who were followed up at two tertiary rheumatology centers, and to find the factors possibly influencing the outcomes of this disease. MATERIAL AND METHODS: Thirty-five patients were followed up prospectively from the onset of disease (the first patient was enrolled in 1994) at Vilnius University Hospital and the Center of Rheumatology of Kaunas University of Medicine (17 and 18 patients, respectively). All patients in both the centers were followed up on a routine basis, and their records contained necessary information about laboratory and biopsy data; the censoring date (end of follow-up) was stated in June 2006. RESULTS: Among the patients, the most frequent organs involved were ear, nose, throat (ENT) (82.6%), lungs (74.3%), and kidney (renal involvement was defined by proteinuria/abnormal urine sediment) (45.7%). Renal insufficiency was present in 20.6% of all the patients. At the end of the study, 32.4% of patients had simultaneously all three organ systems involved, namely upper respiratory tract, pulmonary, and renal. ANCA positivity was found for 26 (74.3%) of all the patients. Overall mortality rate was 25.7% (9/35). The mean survival was 99.4 months (95% CI, 73.6; 125.3) limited to 149 months for the longest-surviving patient. CONCLUSIONS: Female gender and all three specific organ involvements being present at the same time and higher vasculitis damage index were associated with poor outcome. Overall mortality rate was 25.7% (9/35) during the 12-year follow-up, and it is similar to the data from other European countries.
Authors: Godasi S R S N K Naidu; Aman Sharma; Ritambra Nada; Harbir Singh Kohli; Vivekanand Jha; Krishan Lal Gupta; Vinay Sakhuja; Manish Rathi Journal: Rheumatol Int Date: 2014-05-18 Impact factor: 2.631
Authors: Safwat Eldaabossi; Mustafa Saad; Mohammed Alabdullah; Amgad Awad; Hussain Alquraini; Ghada Moumneh; Ali Mansour Journal: Int Med Case Rep J Date: 2021-12-20
Authors: Marek Bohm; Maria Isabel Gonzalez Fernandez; Seza Ozen; Angela Pistorio; Pavla Dolezalova; Paul Brogan; Giancarlo Barbano; Claudia Sengler; Marisa Klein-Gitelman; Pierre Quartier; Anders Fasth; Troels Herlin; Maria Teresa R A Terreri; Susan Nielsen; Marion A J van Rossum; Tadej Avcin; Esteban Rodolfo Castell; Ivan Foeldvari; Dirk Foell; Anuela Kondi; Isabelle Koné-Paut; Rolf-Michael Kuester; Hartmut Michels; Nico Wulffraat; Halima Ben Amer; Clara Malattia; Alberto Martini; Nicolino Ruperto Journal: Pediatr Rheumatol Online J Date: 2014-05-26 Impact factor: 3.054