CONTEXT: Severe sepsis, defined as infection complicated by acute organ dysfunction, occurs more frequently and leads to more deaths in black than in white individuals. The optimal approach to minimize these disparities is unclear. OBJECTIVE: To determine the extent to which higher severe sepsis rates in black than in white patients are due to higher infection rates or to a higher risk of acute organ dysfunction. DESIGN, SETTING, AND PARTICIPANTS: Analysis of infection-related hospitalizations from the 2005 hospital discharge data of 7 US states and infection-related emergency department visits from the 2003-2007 National Hospital Ambulatory Care Survey. MAIN OUTCOME MEASURE: Age- and sex-standardized severe sepsis and infection hospitalization rates and the risk of acute organ dysfunction. RESULTS: Of 8,661,227 non-childbirth-related discharges, 2,261,857 were associated with an infection, and of these, 381,787 (16.8%) had severe sepsis. Black patients had a 67% higher age- and sex-standardized severe sepsis rate than did white patients (9.4; 95% confidence interval [CI], 9.3-9.5 vs 5.6; 95% CI, 5.6-5.6 per 1000 population; P < .001) and 80% higher standardized mortality (1.8, 95% CI, 1.8-1.9 vs 1.0, 95% CI, 1.0-1.1 per 1000 population; P < .001). The higher severe sepsis rate was explained by both a higher infection rate in black patients (47.3; 95% CI, 47.1-47.4 vs 34.0; 95% CI, 33.9-34.0 per 1000 population; incidence rate ratio, 1.39; P < .001) and a higher risk of developing acute organ dysfunction (age- and sex-adjusted odds ratio [OR], 1.29; 95% CI, 1.27-1.30; P < .001). Differences in infection presented broadly across different sites and etiology of infection and for community- and hospital-acquired infections and occurred despite a lower likelihood of being admitted for infection from the emergency department (adjusted OR, 0.70; 95% CI, 0.64-0.76; P < .001). The higher risk of organ dysfunction persisted but was attenuated after adjusting for age, sex, comorbid conditions, poverty, and hospital effect (OR, 1.14; 95% CI, 1.13-1.16; P < .001). Racial disparities in infection and severe sepsis incidence and mortality rates were largest among younger adults (eg, the proportion of invasive pneumococcal disease occurring in adults < 65 years was 73.9% among black patients vs 44.5% among white patients, P < .001). CONCLUSION: Racial differences in severe sepsis are explained by both a higher infection rate and a higher risk of acute organ dysfunction in black than in white individuals.
CONTEXT: Severe sepsis, defined as infection complicated by acute organ dysfunction, occurs more frequently and leads to more deaths in black than in white individuals. The optimal approach to minimize these disparities is unclear. OBJECTIVE: To determine the extent to which higher severe sepsis rates in black than in white patients are due to higher infection rates or to a higher risk of acute organ dysfunction. DESIGN, SETTING, AND PARTICIPANTS: Analysis of infection-related hospitalizations from the 2005 hospital discharge data of 7 US states and infection-related emergency department visits from the 2003-2007 National Hospital Ambulatory Care Survey. MAIN OUTCOME MEASURE: Age- and sex-standardized severe sepsis and infection hospitalization rates and the risk of acute organ dysfunction. RESULTS: Of 8,661,227 non-childbirth-related discharges, 2,261,857 were associated with an infection, and of these, 381,787 (16.8%) had severe sepsis. Black patients had a 67% higher age- and sex-standardized severe sepsis rate than did white patients (9.4; 95% confidence interval [CI], 9.3-9.5 vs 5.6; 95% CI, 5.6-5.6 per 1000 population; P < .001) and 80% higher standardized mortality (1.8, 95% CI, 1.8-1.9 vs 1.0, 95% CI, 1.0-1.1 per 1000 population; P < .001). The higher severe sepsis rate was explained by both a higher infection rate in black patients (47.3; 95% CI, 47.1-47.4 vs 34.0; 95% CI, 33.9-34.0 per 1000 population; incidence rate ratio, 1.39; P < .001) and a higher risk of developing acute organ dysfunction (age- and sex-adjusted odds ratio [OR], 1.29; 95% CI, 1.27-1.30; P < .001). Differences in infection presented broadly across different sites and etiology of infection and for community- and hospital-acquired infections and occurred despite a lower likelihood of being admitted for infection from the emergency department (adjusted OR, 0.70; 95% CI, 0.64-0.76; P < .001). The higher risk of organ dysfunction persisted but was attenuated after adjusting for age, sex, comorbid conditions, poverty, and hospital effect (OR, 1.14; 95% CI, 1.13-1.16; P < .001). Racial disparities in infection and severe sepsis incidence and mortality rates were largest among younger adults (eg, the proportion of invasive pneumococcal disease occurring in adults < 65 years was 73.9% among black patients vs 44.5% among white patients, P < .001). CONCLUSION: Racial differences in severe sepsis are explained by both a higher infection rate and a higher risk of acute organ dysfunction in black than in white individuals.
Authors: Paula A Braveman; Catherine Cubbin; Susan Egerter; Sekai Chideya; Kristen S Marchi; Marilyn Metzler; Samuel Posner Journal: JAMA Date: 2005-12-14 Impact factor: 56.272
Authors: Pierre-Francois Laterre; Gary Garber; Howard Levy; Richard Wunderink; Gary T Kinasewitz; Jean-Pierre Sollet; Dennis G Maki; Becky Bates; Sau Chi Betty Yan; Jean-Francois Dhainaut Journal: Crit Care Med Date: 2005-05 Impact factor: 7.598
Authors: Bart Ferwerda; Matthew B B McCall; Santos Alonso; Evangelos J Giamarellos-Bourboulis; Maria Mouktaroudi; Neskuts Izagirre; Din Syafruddin; Gibson Kibiki; Tudor Cristea; Anneke Hijmans; Lutz Hamann; Shoshana Israel; Gehad ElGhazali; Marita Troye-Blomberg; Oliver Kumpf; Boubacar Maiga; Amagana Dolo; Ogobara Doumbo; Cornelus C Hermsen; Anton F H Stalenhoef; Reinout van Crevel; Han G Brunner; Djin-Ye Oh; Ralf R Schumann; Concepcion de la Rúa; Robert Sauerwein; Bart-Jan Kullberg; André J A M van der Ven; Jos W M van der Meer; Mihai G Netea Journal: Proc Natl Acad Sci U S A Date: 2007-10-09 Impact factor: 11.205
Authors: Amber E Barnato; Sherri L Alexander; Walter T Linde-Zwirble; Derek C Angus Journal: Am J Respir Crit Care Med Date: 2007-11-01 Impact factor: 21.405
Authors: Chiea C Khor; Stephen J Chapman; Fredrik O Vannberg; Aisling Dunne; Caroline Murphy; Edmund Y Ling; Angela J Frodsham; Andrew J Walley; Otto Kyrieleis; Amir Khan; Christophe Aucan; Shelley Segal; Catrin E Moore; Kyle Knox; Sarah J Campbell; Christian Lienhardt; Anthony Scott; Peter Aaby; Oumou Y Sow; Robert T Grignani; Jackson Sillah; Giorgio Sirugo; Nobert Peshu; Thomas N Williams; Kathryn Maitland; Robert J O Davies; Dominic P Kwiatkowski; Nicholas P Day; Djamel Yala; Derrick W Crook; Kevin Marsh; James A Berkley; Luke A J O'Neill; Adrian V S Hill Journal: Nat Genet Date: 2007-02-25 Impact factor: 38.330
Authors: Sara E Erickson; Eduard E Vasilevskis; Michael W Kuzniewicz; Brian A Cason; Rondall K Lane; Mitzi L Dean; Deborah J Rennie; R Adams Dudley Journal: Crit Care Med Date: 2011-03 Impact factor: 7.598
Authors: Kimon L H Ioannides; Avi Baehr; David N Karp; Douglas J Wiebe; Brendan G Carr; Daniel N Holena; M Kit Delgado Journal: Acad Emerg Med Date: 2018-05-31 Impact factor: 3.451
Authors: Justin Xavier Moore; John P Donnelly; Russell Griffin; George Howard; Monika M Safford; Henry E Wang Journal: Crit Care Med Date: 2016-07 Impact factor: 7.598
Authors: O'Dene Lewis; Julius Ngwa; Richard F Gillum; Alicia Thomas; Wayne Davis; Vishal Poddar; George R Adams; Alvin Jr Thomas; Alem Mehari Journal: Ethn Dis Date: 2016-04-21 Impact factor: 1.847
Authors: John E Griepentrog; Xianghong Zhang; Anthony J Lewis; Gianmarino Gianfrate; Hanna E Labiner; Baobo Zou; Zeyu Xiong; Janet S Lee; Matthew R Rosengart Journal: J Leukoc Biol Date: 2019-08-04 Impact factor: 4.962