Literature DB >> 20570747

Genetic management of the Göttingen Minipig population.

Henner Simianer1, Friederike Köhn.   

Abstract

The Göttingen Minipig is a laboratory animal of worldwide importance. The breed was developed in the 1960's at the University of Göttingen, Germany, using the founder breeds Minnesota Minipigs, Vietnamese Potbelly Pig and German Landrace. After the initial period under free range conditions the population was stocked under high hygienic standards. In 1992 an exclusive licence contract was made between Ellegaard Göttingen Minipigs ApS in Denmark and the University of Göttingen. Since 2002 the production and marketing of Göttingen Minipigs in the USA is managed by Marshall Farms, Inc. under licence from Ellegaard Göttingen Minipigs A/S. Today, there are three Danish, one American and one German population. The genetic management for all populations is provided by the University of Göttingen. The main focus is the maintenance and reduction of inbreeding and genetic drift, the maintenance of a high degree of uniformity and genetic progress in the main selection traits. The main selection trait in the past was the number of piglets born alive. By producing many piglets per sow and year, a fast genetic exchange of breeding animals could be achieved leading to a minimised inbreeding in the populations. To satisfy the market demands of a small and easy to handle minipig and to overcome the problem of an antagonistic relationship between litter size and body weight, the trait body weight reduction was included in the selection scheme using a restricted selection index. It is planned for the future to include temperament traits in the breeding scheme. Due to fast developments in genome-based breeding applications, these new methods can soon be implemented for an efficient control of genetic drift and inbreeding or even for genome-based selection.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID: 20570747     DOI: 10.1016/j.vascn.2010.05.004

Source DB:  PubMed          Journal:  J Pharmacol Toxicol Methods        ISSN: 1056-8719            Impact factor:   1.950


  18 in total

1.  Novel technique for retroperitoneal implantation of telemetry transmitters for physiologic monitoring in Göttingen minipigs (Sus scrofa domesticus).

Authors:  Scott Willens; David M Cox; Ernest H Braue; Todd M Myers; Matthew D Wegner
Journal:  Comp Med       Date:  2014-12       Impact factor: 0.982

2.  Selective Insulin-like Growth Factor Resistance Associated with Heart Hemorrhages and Poor Prognosis in a Novel Preclinical Model of the Hematopoietic Acute Radiation Syndrome.

Authors:  Doreswamy Kenchegowda; Betre Legesse; Bernadette Hritzo; Cara Olsen; Saeed Aghdam; Amandeep Kaur; William Culp; Alexandrine Derrien-Colemyn; Grant Severson; Maria Moroni
Journal:  Radiat Res       Date:  2018-05-29       Impact factor: 2.841

Review 3.  A physiologically based pharmacokinetic model of the minipig: data compilation and model implementation.

Authors:  Claudia Suenderhauf; Neil Parrott
Journal:  Pharm Res       Date:  2012-11-21       Impact factor: 4.200

4.  Utility of Göttingen minipigs for Prediction of Human Pharmacokinetic Profiles After Dermal Drug Application.

Authors:  Syunsuke Yamamoto; Masatoshi Karashima; Noriyasu Sano; Chiharu Fukushi; Kimio Tohyama; Yuta Arai; Hideki Hirabayashi; Nobuyuki Amano
Journal:  Pharm Res       Date:  2017-08-21       Impact factor: 4.200

5.  Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

Authors:  Yanan Zheng; Devin B Tesar; Lisa Benincosa; Herbert Birnböck; C Andrew Boswell; Daniela Bumbaca; Kyra J Cowan; Dimitry M Danilenko; Ann L Daugherty; Paul J Fielder; Hans Peter Grimm; Amita Joshi; Nicole Justies; Gerry Kolaitis; Nicholas Lewin-Koh; Jing Li; Sami McVay; Jennifer O'Mahony; Michael Otteneder; Michael Pantze; Wendy S Putnam; Zhihua J Qiu; Jane Ruppel; Thomas Singer; Oliver Stauch; Frank-Peter Theil; Jennifer Visich; Jihong Yang; Yong Ying; Leslie A Khawli; Wolfgang F Richter
Journal:  MAbs       Date:  2012-03-01       Impact factor: 5.857

6.  Pig gene knockout by rAAV-mediated homologous recombination: comparison of BRCA1 gene knockout efficiency in Yucatan and Göttingen fibroblasts with slightly different target sequences.

Authors:  Yonglun Luo; Lars Bolund; Charlotte Brandt Sørensen
Journal:  Transgenic Res       Date:  2011-10-22       Impact factor: 2.788

7.  Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach.

Authors:  Floriane Lignet; Eva Sherbetjian; Nicole Kratochwil; Russell Jones; Claudia Suenderhauf; Michael B Otteneder; Thomas Singer; Neil Parrott
Journal:  Pharm Res       Date:  2016-07-28       Impact factor: 4.200

8.  Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain.

Authors:  Laura J Mahady; Sylvia E Perez; Dwaine F Emerich; Lars U Wahlberg; Elliott J Mufson
Journal:  J Comp Neurol       Date:  2016-08-30       Impact factor: 3.215

9.  Hematological changes as prognostic indicators of survival: similarities between Gottingen minipigs, humans, and other large animal models.

Authors:  Maria Moroni; Eric Lombardini; Rudolph Salber; Mehdi Kazemzedeh; Vitaly Nagy; Cara Olsen; Mark H Whitnall
Journal:  PLoS One       Date:  2011-09-28       Impact factor: 3.240

10.  Functional analysis and transcriptional output of the Göttingen minipig genome.

Authors:  Tobias Heckel; Roland Schmucki; Marco Berrera; Stephan Ringshandl; Laura Badi; Guido Steiner; Morgane Ravon; Erich Küng; Bernd Kuhn; Nicole A Kratochwil; Georg Schmitt; Anna Kiialainen; Corinne Nowaczyk; Hamina Daff; Azinwi Phina Khan; Isaac Lekolool; Roger Pelle; Edward Okoth; Richard Bishop; Claudia Daubenberger; Martin Ebeling; Ulrich Certa
Journal:  BMC Genomics       Date:  2015-11-14       Impact factor: 3.969

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