| Literature DB >> 20570148 |
Kenneth Down1, Paul Bamborough, Catherine Alder, Amanda Campbell, John A Christopher, Maria Gerelle, Steve Ludbrook, Dave Mallett, Geoff Mellor, David D Miller, Rosannah Pearson, Keith Ray, Yemisi Solanke, Don Somers.
Abstract
A novel pyrrole-2-carboxamide series of p38alpha inhibitors, discovered through the application of virtual screening, is presented. Following evaluation of activity, selectivity and developability properties of commercially available analogues, a synthesis program enabled rapid assessment of the series' suitability for further lead optimisation studies. 2010 Elsevier Ltd. All rights reserved.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20570148 DOI： 10.1016/j.bmcl.2010.05.011
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823