BACKGROUND: Severe mental disorders are associated with elevated levels of inflammatory markers. In the present study, we investigated whether osteoprotegerin (OPG), a member of the tumour necrosis factor receptor family involved in calcification and inflammation, is elevated in patients with severe mental disorders. METHODS: We measured the plasma levels of OPG in patients with severe mental disorders (n = 312; 125 with bipolar disorder and 187 with schizophrenia) and healthy volunteers (n = 239). RESULTS: The mean plasma levels of OPG were significantly higher in patients than in controls (t531 = 2.6, p = 0.01), with the same pattern in bipolar disorder and schizophrenia. The increase was significant after adjustment for possible confounding variables, including age, sex, ethnic background, alcohol consumption, liver and kidney function, diabetes, cardiovascular disease, autoimmune diseases and levels of cholesterol, glucose and C-reactive protein. LIMITATIONS: Owing to the cross-sectional design, it is difficult to determine causality. CONCLUSION: Our results indicate that elevated OPG levels are associated with severe mental disorders and suggest that mechanisms related to calcification and inflammation may play a role in disease development.
BACKGROUND: Severe mental disorders are associated with elevated levels of inflammatory markers. In the present study, we investigated whether osteoprotegerin (OPG), a member of the tumour necrosis factor receptor family involved in calcification and inflammation, is elevated in patients with severe mental disorders. METHODS: We measured the plasma levels of OPG in patients with severe mental disorders (n = 312; 125 with bipolar disorder and 187 with schizophrenia) and healthy volunteers (n = 239). RESULTS: The mean plasma levels of OPG were significantly higher in patients than in controls (t531 = 2.6, p = 0.01), with the same pattern in bipolar disorder and schizophrenia. The increase was significant after adjustment for possible confounding variables, including age, sex, ethnic background, alcohol consumption, liver and kidney function, diabetes, cardiovascular disease, autoimmune diseases and levels of cholesterol, glucose and C-reactive protein. LIMITATIONS: Owing to the cross-sectional design, it is difficult to determine causality. CONCLUSION: Our results indicate that elevated OPG levels are associated with severe mental disorders and suggest that mechanisms related to calcification and inflammation may play a role in disease development.
Authors: M Takami; N Takahashi; N Udagawa; C Miyaura; K Suda; J T Woo; T J Martin; K Nagai; T Suda Journal: Endocrinology Date: 2000-12 Impact factor: 4.736
Authors: Roosmarijn C Drexhage; Esther M Knijff; Roos C Padmos; Leonie van der Heul-Nieuwenhuijzen; Wouter Beumer; Marjan A Versnel; Hemmo A Drexhage Journal: Expert Rev Neurother Date: 2010-01 Impact factor: 4.618
Authors: Paul Lichtenstein; Benjamin H Yip; Camilla Björk; Yudi Pawitan; Tyrone D Cannon; Patrick F Sullivan; Christina M Hultman Journal: Lancet Date: 2009-01-17 Impact factor: 79.321
Authors: William J McBride; Mark W Kimpel; Jeanette N McClintick; Zheng-Ming Ding; Howard J Edenberg; Tiebing Liang; Zachary A Rodd; Richard L Bell Journal: Pharmacol Biochem Behav Date: 2013-12-16 Impact factor: 3.533
Authors: O A Andreassen; H F Harbo; Y Wang; W K Thompson; A J Schork; M Mattingsdal; V Zuber; F Bettella; S Ripke; J R Kelsoe; K S Kendler; M C O'Donovan; P Sklar; L K McEvoy; R S Desikan; B A Lie; S Djurovic; A M Dale Journal: Mol Psychiatry Date: 2014-01-28 Impact factor: 15.992
Authors: Kazim Sahin; Cemal Orhan; Serdar Karatoprak; Mehmet Tuzcu; Patrick Brice Defo Deeh; Ibrahim Hanifi Ozercan; Nurhan Sahin; Merve Yilmaz Bozoglan; Sarah Sylla; Sara Perez Ojalvo; James R Komorowski Journal: Nutrients Date: 2022-03-17 Impact factor: 5.717