Literature DB >> 20569230

Addiction research centres and the nurturing of creativity: the National Institute on Alcohol Abuse and Alcoholism.

Markus Heilig1, Kenneth R Warren, George Kunos, Peter B Silverman, Brenda G Hewitt.   

Abstract

The aim of this paper is to present a concise account of the history, mission, structure and some recent achievements of the US National Institute on Alcohol Abuse and Alcoholism (NIAAA). Created by the US Congress 40 years ago, the NIAAA has evolved from an entity charged mainly with building a national system of alcoholism treatment services to one with responsibility for developing, nurturing and supporting the biomedical and behavioral science foundation necessary to reduce the significant domestic and global public health impact of alcohol use disorders. The NIAAA is unique in that it functions both as a funding agency, supporting research at universities and other external, or 'extramural' research institutions, and is also a research institution itself, where alcohol research is carried out in-house, or 'intramurally'. Of a $450.2 million 2009 Congressional Appropriation, approximately 90% was devoted toward the former and approximately 10% towards the latter objective. The current NIAAA Strategic Plan builds on a new organizing principle for long-range research planning, based on a life-span perspective that recognizes that human biology and behavior continue to change throughout life and changes occurring throughout the life-span affect individuals' drinking patterns as well as the decisions they may make to change their drinking habits or to seek help for alcohol use problems. Within this framework, major efforts are currently being devoted to educating practitioners on clinically useful, science-based assessment and treatment methods that exist today, and development of personalized new treatments for tomorrow.
© 2010 The Authors. Journal compilation © 2010 Society for the Study of Addiction.

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Year:  2010        PMID: 20569230      PMCID: PMC3024445          DOI: 10.1111/j.1360-0443.2010.02995.x

Source DB:  PubMed          Journal:  Addiction        ISSN: 0965-2140            Impact factor:   6.526


  10 in total

1.  Structural rearrangement of CaMKIIalpha catalytic domains encodes activation.

Authors:  Christopher Thaler; Srinagesh V Koushik; Henry L Puhl; Paul S Blank; Steven S Vogel
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-01       Impact factor: 11.205

2.  Chronic stress causes frontostriatal reorganization and affects decision-making.

Authors:  Eduardo Dias-Ferreira; João C Sousa; Irene Melo; Pedro Morgado; Ana R Mesquita; João J Cerqueira; Rui M Costa; Nuno Sousa
Journal:  Science       Date:  2009-07-31       Impact factor: 47.728

3.  Reports from research centres--12. National Institute on Alcohol Abuse and Alcoholism.

Authors:  E Gordis
Journal:  Br J Addict       Date:  1988-05

4.  Alterations in brain glucose utilization accompanying elevations in blood ethanol and acetate concentrations in the rat.

Authors:  Robert J Pawlosky; Yoshihiro Kashiwaya; Shireesh Srivastava; Michael T King; Calvin Crutchfield; Nora Volkow; George Kunos; Ting-Kai Li; Richard L Veech
Journal:  Alcohol Clin Exp Res       Date:  2009-11-24       Impact factor: 3.455

5.  Genetic variation in human NPY expression affects stress response and emotion.

Authors:  Zhifeng Zhou; Guanshan Zhu; Ahmad R Hariri; Mary-Anne Enoch; David Scott; Rajita Sinha; Matti Virkkunen; Deborah C Mash; Robert H Lipsky; Xian-Zhang Hu; Colin A Hodgkinson; Ke Xu; Beata Buzas; Qiaoping Yuan; Pei-Hong Shen; Robert E Ferrell; Stephen B Manuck; Sarah M Brown; Richard L Hauger; Christian S Stohler; Jon-Kar Zubieta; David Goldman
Journal:  Nature       Date:  2008-04-02       Impact factor: 49.962

6.  Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice.

Authors:  Douglas Osei-Hyiaman; Jie Liu; Liang Zhou; Grzegorz Godlewski; Judith Harvey-White; Won-il Jeong; Sándor Bátkai; Giovanni Marsicano; Beat Lutz; Christoph Buettner; George Kunos
Journal:  J Clin Invest       Date:  2008-09       Impact factor: 14.808

7.  Neurokinin 1 receptor antagonism as a possible therapy for alcoholism.

Authors:  David T George; Jodi Gilman; Jacqueline Hersh; Annika Thorsell; David Herion; Christopher Geyer; Xiaomei Peng; William Kielbasa; Robert Rawlings; John E Brandt; Donald R Gehlert; Johannes T Tauscher; Stephen P Hunt; Daniel Hommer; Markus Heilig
Journal:  Science       Date:  2008-02-14       Impact factor: 47.728

8.  Sociodemographic and psychopathologic predictors of first incidence of DSM-IV substance use, mood and anxiety disorders: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions.

Authors:  B F Grant; R B Goldstein; S P Chou; B Huang; F S Stinson; D A Dawson; T D Saha; S M Smith; A J Pulay; R P Pickering; W J Ruan; W M Compton
Journal:  Mol Psychiatry       Date:  2008-04-22       Impact factor: 15.992

9.  Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.

Authors:  Won-il Jeong; Douglas Osei-Hyiaman; Ogyi Park; Jie Liu; Sándor Bátkai; Partha Mukhopadhyay; Norio Horiguchi; Judith Harvey-White; Giovanni Marsicano; Beat Lutz; Bin Gao; George Kunos
Journal:  Cell Metab       Date:  2008-03       Impact factor: 27.287

10.  Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study.

Authors:  Joseph R Hibbeln; John M Davis; Colin Steer; Pauline Emmett; Imogen Rogers; Cathy Williams; Jean Golding
Journal:  Lancet       Date:  2007-02-17       Impact factor: 79.321

  10 in total

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