INTRODUCTION: Because the normal ovary is assumed to be devoid of lymphoid tissue, it is unusual for it to be an initial manifestation of malignant lymphoma. This case is the first report, to our knowledge, of post-transplant lymphoproliferative disorder involving the ovary as an initial manifestation. CASE PRESENTATION: Twenty-nine weeks after a living renal transplantation, a 38-year-old Japanese female, whose ethnic origin was Asian, presented with abdominal pain and a chronic high fever. Computed tomography revealed a right ovarian tumor and liver metastases. The patient underwent oophrectomy based on the clinical diagnosis of liver metastasis from the primary ovarian tumor. The pathological diagnosis was Epstein-Barr Virus-associated post-transplant lymphoproliferative disorder. While ovarian malignant lymphoma has a poor prognosis, complete remission of liver involvement in this case was achieved only with a reduction of immunosuppressants. CONCLUSION: Clinicians should remember that malignant lymphoma could initially involve the ovary, especially if the patient is immunosuppressed after transplantation therapy.
INTRODUCTION: Because the normal ovary is assumed to be devoid of lymphoid tissue, it is unusual for it to be an initial manifestation of malignant lymphoma. This case is the first report, to our knowledge, of post-transplant lymphoproliferative disorder involving the ovary as an initial manifestation. CASE PRESENTATION: Twenty-nine weeks after a living renal transplantation, a 38-year-old Japanese female, whose ethnic origin was Asian, presented with abdominal pain and a chronic high fever. Computed tomography revealed a right ovarian tumor and liver metastases. The patient underwent oophrectomy based on the clinical diagnosis of liver metastasis from the primary ovarian tumor. The pathological diagnosis was Epstein-Barr Virus-associated post-transplant lymphoproliferative disorder. While ovarian malignant lymphoma has a poor prognosis, complete remission of liver involvement in this case was achieved only with a reduction of immunosuppressants. CONCLUSION: Clinicians should remember that malignant lymphoma could initially involve the ovary, especially if the patient is immunosuppressed after transplantation therapy.
Authors: R Shapiro; M Nalesnik; J McCauley; S Fedorek; M L Jordan; V P Scantlebury; A Jain; C Vivas; D Ellis; S Lombardozzi-Lane; P Randhawa; J Johnston; T R Hakala; R L Simmons; J J Fung; T E Starzl Journal: Transplantation Date: 1999-12-27 Impact factor: 4.939
Authors: D E Tsai; C L Hardy; J E Tomaszewski; R M Kotloff; K M Oltoff; B G Somer; S J Schuster; D L Porter; K T Montone; E A Stadtmauer Journal: Transplantation Date: 2001-04-27 Impact factor: 4.939
Authors: Vahakn B Shahinian; Norman Muirhead; Anthony M Jevnikar; Stephen H Leckie; Anand K Khakhar; Patrick P Luke; Kamilia S Rizkalla; David J Hollomby; Andrew A House Journal: Transplantation Date: 2003-03-27 Impact factor: 4.939
Authors: Ralf Trappe; Hanno Riess; Nina Babel; Manfred Hummel; Hans Lehmkuhl; Sven Jonas; Ioannis Anagnostopoulos; Matthias Papp-Vary; Petra Reinke; Roland Hetzer; Bernd Dörken; Stephan Oertel Journal: Transplantation Date: 2007-04-15 Impact factor: 4.939