Literature DB >> 2056530

DNA looping alters local DNA conformation during transcription.

H Y Wu1, L F Liu.   

Abstract

The effect of protein-mediated DNA looping on local DNA conformation during active transcription was studied using the lac repressor-operator system. Our results suggest that lac repressor-mediated DNA looping within a plasmid DNA molecule containing two lac repressor binding sequences in vivo effectively separates plasmid DNA into two topological domains. Supercoils generated by transcription within each topological domain can be rapidly removed by DNA topoisomerase I.

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Year:  1991        PMID： 2056530     DOI： 10.1016/0022-2836(91)90658-s

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  18 in total

1.  Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status.

Authors:  Yinghui Mao; Issac R Mehl; Mark T Muller
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-22       Impact factor: 11.205

2.  Disconnecting XRCC1 and DNA ligase III.

Authors:  Sachin Katyal; Peter J McKinnon
Journal:  Cell Cycle       Date:  2011-07-15       Impact factor: 4.534

3.  Identification of a DNA supercoiling activity in Saccharomyces cerevisiae.

Authors:  H S Koo; K Lau; H Y Wu; L F Liu
Journal:  Nucleic Acids Res       Date:  1992-10-11       Impact factor: 16.971

4.  Dividing a supercoiled DNA molecule into two independent topological domains.

Authors:  Fenfei Leng; Bo Chen; David D Dunlap
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-28       Impact factor: 11.205

5.  Supercoiling affects the accessibility of glutathione to DNA-bound molecules: positive supercoiling inhibits calicheamicin-induced DNA damage.

Authors:  W A LaMarr; L Yu; K C Nicolaou; P C Dedon
Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-06       Impact factor: 11.205

6.  Long-distance effect of downstream transcription on activity of the supercoiling-sensitive leu-500 promoter in a topA mutant of Salmonella typhimurium.

Authors:  F Spirito; L Bossi
Journal:  J Bacteriol       Date:  1996-12       Impact factor: 3.490

Review 7.  Protein-induced DNA linking number change by sequence-specific DNA binding proteins and its biological effects.

Authors:  Fenfei Leng
Journal:  Biophys Rev       Date:  2016-06-10

Review 8.  Protein-induced DNA linking number change by sequence-specific DNA binding proteins and its biological effects.

Authors:  Fenfei Leng
Journal:  Biophys Rev       Date:  2016-11-14

9.  Modulation of gyrase-mediated DNA cleavage and cell killing by ATP.

Authors:  T K Li; L F Liu
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

Review 10.  Topological Behavior of Plasmid DNA.

Authors:  N Patrick Higgins; Alexander V Vologodskii
Journal:  Microbiol Spectr       Date:  2015-04
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