BACKGROUND: Although awareness of the relevance of leprosy and human immunodeficiency virus (HIV) coinfection is increasing worldwide, several aspects of this co-occurrence are not fully understood. METHODS: We describe clinical, pathological, immunological, and therapeutic long-term follow-up of a cohort of 25 individuals with leprosy and HIV infection from Manaus, Amazonas. RESULTS: Careful description of our cohort indicates a higher prevalence of leprosy in an HIV-positive population than that in the general population. We also observed upgrading shifting of leprosy clinical forms after initiation of highly active antiretroviral therapy and multidrug therapy and an impact of HIV infection on leprosy granuloma formation, among other features. CONCLUSION: Taken together, these new insights allow the proposition of a classification system that includes (1) leprosy and HIV true coinfection, (2) opportunistic leprosy disease, and (3) leprosy related to highly active antiretroviral therapy.
BACKGROUND: Although awareness of the relevance of leprosy and human immunodeficiency virus (HIV) coinfection is increasing worldwide, several aspects of this co-occurrence are not fully understood. METHODS: We describe clinical, pathological, immunological, and therapeutic long-term follow-up of a cohort of 25 individuals with leprosy and HIV infection from Manaus, Amazonas. RESULTS: Careful description of our cohort indicates a higher prevalence of leprosy in an HIV-positive population than that in the general population. We also observed upgrading shifting of leprosy clinical forms after initiation of highly active antiretroviral therapy and multidrug therapy and an impact of HIV infection on leprosy granuloma formation, among other features. CONCLUSION: Taken together, these new insights allow the proposition of a classification system that includes (1) leprosy and HIV true coinfection, (2) opportunistic leprosy disease, and (3) leprosy related to highly active antiretroviral therapy.
Authors: Ariane Leite de Oliveira; Thaís Porto Amadeu; Andressa Cristina de França Gomes; Vinícius Martins Menezes; José Augusto da Costa Nery; Roberta Olmo Pinheiro; Euzenir Nunes Sarno Journal: Immunology Date: 2013-09 Impact factor: 7.397
Authors: Carmem Beatriz Wagner Giacoia-Gripp; Anna Maria Sales; José Augusto da Costa Nery; Joanna Reis Santos-Oliveira; Ariane Leite de Oliveira; Euzenir Nunes Sarno; Mariza Gonçalves Morgado Journal: PLoS One Date: 2011-12-21 Impact factor: 3.240
Authors: Carla Andréa Avelar Pires; Mario Fernando Ribeiro de Miranda; Maraya de Jesus Semblano Bittencourt; Arival Cardoso de Brito; Marília Brasil Xavier Journal: An Bras Dermatol Date: 2015 Jan-Feb Impact factor: 1.896
Authors: Marilia Brasil Xavier; Mariana Garcia Borges do Nascimento; Keila de Nazare Madureira Batista; Danusa Neves Somensi; Fernando Octavio Machado Juca Neto; Thomaz Xavier Carneiro; Claudia Maria Castro Gomes; Carlos Eduardo Pereira Corbett Journal: PLoS Negl Trop Dis Date: 2018-07-18
Authors: Paulo R L Machado; Lídia M Machado; Mayume Shibuya; Jamile Rego; Warren D Johnson; Marshall J Glesby Journal: PLoS Negl Trop Dis Date: 2015-08-12