Literature DB >> 20565110

Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.

Tobias Karlberg1, Natalia Markova, Ida Johansson, Martin Hammarström, Patrick Schütz, Johan Weigelt, Herwig Schüler.   

Abstract

We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. The complex of TNKS2 with the potent inhibitor XAV939 provides insights into the molecular basis of the strong interaction and suggests routes for further development of tankyrase inhibitors.

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Year:  2010        PMID： 20565110     DOI： 10.1021/jm100249w

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  43 in total

1.  Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment.

Authors:  Seamus Morrone; Zhihong Cheng; Randall T Moon; Feng Cong; Wenqing Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-17       Impact factor: 11.205

Review 2.  Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.

Authors:  Shilong Zheng; Jiawang Liu; Yanyuan Wu; Tien L Huang; Guangdi Wang
Journal:  Future Med Chem       Date:  2015-12-16       Impact factor: 3.808

3.  Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.

Authors:  Tobias Karlberg; Mirjam Klepsch; Ann-Gerd Thorsell; C David Andersson; Anna Linusson; Herwig Schüler
Journal:  J Biol Chem       Date:  2015-01-29       Impact factor: 5.157

4.  Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase Inhibitors.

Authors:  Javier de Vicente; Parcharee Tivitmahaisoon; Pamela Berry; David R Bolin; Daisy Carvajal; Wei He; Kuo-Sen Huang; Cheryl Janson; Lena Liang; Christine Lukacs; Ann Petersen; Hong Qian; Lin Yi; Yong Zhuang; Johannes C Hermann
Journal:  ACS Med Chem Lett       Date:  2015-08-04       Impact factor: 4.345

5.  Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.

Authors:  Ann-Gerd Thorsell; Torun Ekblad; Tobias Karlberg; Mirjam Löw; Ana Filipa Pinto; Lionel Trésaugues; Martin Moche; Michael S Cohen; Herwig Schüler
Journal:  J Med Chem       Date:  2016-12-21       Impact factor: 7.446

6.  Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.

Authors:  Elisabet Wahlberg; Tobias Karlberg; Ekaterina Kouznetsova; Natalia Markova; Antonio Macchiarulo; Ann-Gerd Thorsell; Ewa Pol; Åsa Frostell; Torun Ekblad; Delal Öncü; Björn Kull; Graeme Michael Robertson; Roberto Pellicciari; Herwig Schüler; Johan Weigelt
Journal:  Nat Biotechnol       Date:  2012-02-19       Impact factor: 54.908

7.  Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.

Authors:  Andrés Gambini; Paula Stein; Virginia Savy; Edward J Grow; Brian N Papas; Yingpei Zhang; Anna C Kenan; Elizabeth Padilla-Banks; Bradley R Cairns; Carmen J Williams
Journal:  Dev Cell       Date:  2020-05-21       Impact factor: 12.270

8.  Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors.

Authors:  Paride Liscio; Andrea Carotti; Stefania Asciutti; Tobias Karlberg; Daniele Bellocchi; Laura Llacuna; Antonio Macchiarulo; Stuart A Aaronson; Herwig Schüler; Roberto Pellicciari; Emidio Camaioni
Journal:  J Med Chem       Date:  2014-02-24       Impact factor: 7.446

9.  Evolutionary history of the poly(ADP-ribose) polymerase gene family in eukaryotes.

Authors:  Matteo Citarelli; Sachin Teotia; Rebecca S Lamb
Journal:  BMC Evol Biol       Date:  2010-10-13       Impact factor: 3.260

Review 10.  PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.

Authors:  Marie-France Langelier; John M Pascal
Journal:  Curr Opin Struct Biol       Date:  2013-01-16       Impact factor: 6.809
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