Literature DB >> 20564658

Management of laryngeal premalignant lesions in the Netherlands.

Stijn A J H M Fleskens1, Jeroen A W M van der Laak, Pieter J Slootweg, Robert P Takes.   

Abstract

OBJECTIVES/HYPOTHESIS: To investigate the current clinical management of laryngeal mucosal premalignant lesions (LMPLs) among otorhinolaryngologists working in university hospitals (tertiary referral centers) and nonuniversity hospitals (secondary referral centers) in The Netherlands. Then to compare the investigated practice with the results published in the literature. STUDY
DESIGN: Cross-sectional study.
METHODS: A survey was conducted to assess the management of LMPLs. The questionnaire consisted of a systematic series of figures representing the initial presentation of a patient with a leukoplakic lesion at 12 different anatomical locations. The study group consisted of otorhinolaryngologists at all eight tertiary referral centers in The Netherlands (n = 22) and a random selection of otorhinolaryngologists (n = 25) from secondary referral centers throughout the country.
RESULTS: Comparing the initial management (surgical excision versus biopsy) preferred by otorhinolaryngologists at tertiary referral centers with that preferred by those at secondary referral centers, significant differences were found for seven anatomical locations. Notable differences were observed concerning the treatment of glottic lesions and the management of mild to moderate dysplasia after biopsy. Among the different tertiary referral centers, no uniform preference in management was noticed.
CONCLUSIONS: There are significant differences in the management of LPMLs between otorhinolaryngologists at tertiary and secondary referral centers, depending on the location and histopathology of the lesions. Consensus on and development of guidelines concerning the management of LMPLs could be useful to optimize the diagnosis, treatment, and follow-up of these lesions.

Entities:  

Mesh:

Year:  2010        PMID: 20564658     DOI: 10.1002/lary.20888

Source DB:  PubMed          Journal:  Laryngoscope        ISSN: 0023-852X            Impact factor:   3.325


  6 in total

1.  Guidelines for the Surgical Management of Laryngeal Cancer: Korean Society of Thyroid-Head and Neck Surgery.

Authors:  Soon-Hyun Ahn; Hyun Jun Hong; Soon Young Kwon; Kee Hwan Kwon; Jong-Lyel Roh; Junsun Ryu; Jun Hee Park; Seung-Kuk Baek; Guk Haeng Lee; Sei Young Lee; Jin Choon Lee; Man Ki Chung; Young Hoon Joo; Yong Bae Ji; Jeong Hun Hah; Minsu Kwon; Young Min Park; Chang Myeon Song; Sung-Chan Shin; Chang Hwan Ryu; Doh Young Lee; Young Chan Lee; Jae Won Chang; Ha Min Jeong; Jae-Keun Cho; Wonjae Cha; Byung Joon Chun; Ik Joon Choi; Hyo Geun Choi; Kang Dae Lee
Journal:  Clin Exp Otorhinolaryngol       Date:  2017-01-03       Impact factor: 3.372

2.  SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/β-catenin pathway.

Authors:  Ning Yang; Yan Wang; Lian Hui; Xiaotian Li; Xuejun Jiang
Journal:  Tumour Biol       Date:  2015-06-04

3.  A decade of laryngeal dysplasia in Paisley, Scotland.

Authors:  Jenny Montgomery; Aileen White
Journal:  Eur Arch Otorhinolaryngol       Date:  2011-07-08       Impact factor: 2.503

4.  Role of Frozen Biopsy in Glottic Premalignant Lesions.

Authors:  Young Ju Jin; Woo-Jin Jeong; Jin Ho Paik; Soon-Hyun Ahn
Journal:  Pathol Oncol Res       Date:  2016-11-05       Impact factor: 3.201

5.  The up-regulation expression of APRIL is a marker of glottic malignant disease.

Authors:  Meng Lian; Jugao Fang; Demin Han; Hongzhi Ma; Ru Wang; Fan Yang
Journal:  Eur Arch Otorhinolaryngol       Date:  2013-11-26       Impact factor: 2.503

6.  Microarray gene expression analysis of tumorigenesis and regional lymph node metastasis in laryngeal squamous cell carcinoma.

Authors:  Meng Lian; Jugao Fang; Demin Han; Hongzhi Ma; Ling Feng; Ru Wang; Fan Yang
Journal:  PLoS One       Date:  2013-12-26       Impact factor: 3.240

  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.