| Literature DB >> 20564494 |
Samra Bashir1, Anwar H Gilani, Anwar A Siddiqui, Shahid Pervez, Saeed R Khan, Noor Jehan Sarfaraz, Abdul Jabbar Shah.
Abstract
Berberis vulgaris is a widely used plant for the treatment of urolithiasis. To evaluate its antiurolithic potential, the crude aqueous-methanol extract of Berberis vulgaris root bark (Bv.Cr) was tested in an animal model of urolithiasis, developed in male Wistar rats by adding 0.75% ethylene glycol in drinking water. Bv.Cr (50 mg/kg) inhibited CaOx crystal deposition in renal tubules and protected against associated changes including polyuria, weight loss, impaired renal function and the development of oxidative stress in kidneys. Activity-guided fractionation revealed the concentration of antiurolithic constituent(s) mainly in the aqueous fraction. These data, indicating the presence of antiurolithic activity in Berberis vulgaris root bark, rationalize its medicinal use for the treatment of urolithiasis. Copyright (c) 2010 John Wiley & Sons, Ltd.Entities:
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Year: 2010 PMID： 20564494 DOI： 10.1002/ptr.3196
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878