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Literature DB >> 20564186

Expression of a novel tropomyosin isoform in axolotl heart and skeletal muscle.

Anish Thomas¹, Sudarsan Rajan, Harold L Thurston, Sreeharsha N Masineni, Preeti Dube, Abhishek Bose, Vasundhara Muthu, Syamalima Dube, David F Wieczorek, Bernard J Poiesz, Dipak K Dube.

Abstract

TPM1kappa is an alternatively spliced isoform of the TPM1 gene whose specific role in cardiac development and disease is yet to be elucidated. Although mRNA studies have shown TPM1kappa expression in axolotl heart and skeletal muscle, it has not been quantified. Also the presence of TPM1kappa protein in axolotl heart and skeletal muscle has not been demonstrated. In this study, we quantified TPM1kappa mRNA expression in axolotl heart and skeletal muscle. Using a newly developed TPM1kappa specific antibody, we demonstrated the expression and incorporation of TPM1kappa protein in myofibrils of axolotl heart and skeletal muscle. The results support the potential role of TPM1kappa in myofibrillogenesis and sarcomeric function. J. Cell. Biochem. 110: 875-881, 2010. (c) 2010 Wiley-Liss, Inc.

Entities: CellLine Chemical Disease Gene Species

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Year: 2010 PMID： 20564186 PMCID： PMC2895019 DOI： 10.1002/jcb.22599

Source DB: PubMed Journal: J Cell Biochem ISSN： 0730-2312 Impact factor: 4.429

15 in total

Review 1. The molecular basis for tropomyosin isoform diversity.

Authors: J P Lees-Miller; D M Helfman
Journal: Bioessays Date: 1991-09 Impact factor: 4.345

Review 2. Functional properties of non-muscle tropomyosin isoforms.

Authors: M F Pittenger; J A Kazzaz; D M Helfman
Journal: Curr Opin Cell Biol Date: 1994-02 Impact factor: 8.382

3. Differential expression of a novel isoform of alpha-tropomyosin in cardiac and skeletal muscle of the Mexican axolotl (Ambystoma mexicanum).

Authors: E A Luque; B J Spinner; S Dube; D K Dube; L F Lemanski
Journal: Gene Date: 1997-02-07 Impact factor: 3.688

4. Characterization of a TM-4 type tropomyosin that is essential for myofibrillogenesis and contractile activity in embryonic hearts of the Mexican axolotl.

Authors: Belinda J Spinner; Robert W Zajdel; Matthew D McLean; Christopher R Denz; Syamalima Dube; Sonali Mehta; Aruna Choudhury; Masako Nakatsugawa; Nancy Dobbins; Larry F Lemanski; Dipak K Dube
Journal: J Cell Biochem Date: 2002 Impact factor: 4.429

5. Morphology of developing heart in cardiac lethal mutant Mexican axolotls, Ambystoma mexicanum.

Authors: L F Lemanski
Journal: Dev Biol Date: 1973-08 Impact factor: 3.582

6. Expression of a novel cardiac-specific tropomyosin isoform in humans.

Authors: Christopher R Denz; Aruna Narshi; Robert W Zajdel; Dipak K Dube
Journal: Biochem Biophys Res Commun Date: 2004-08-06 Impact factor: 3.575

7. Genetic and experimental studies on a mutant gene (c) determining absence of heart action in embryos of the Mexican axolotl (Ambystoma mexicanum).

Authors: R R Humphrey
Journal: Dev Biol Date: 1972-03 Impact factor: 3.582

8. Identification, characterization, and expression of a novel alpha-tropomyosin isoform in cardiac tissues in developing chicken.

Authors: Robert W Zajdel; Christopher R Denz; Sung Lee; Syamalima Dube; Elisabeth Ehler; Evylene Perriard; Jean-Claude Perriard; Dipak K Dube
Journal: J Cell Biochem Date: 2003-06-01 Impact factor: 4.429

9. Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform.

Authors: Sudarsan Rajan; Ganapathy Jagatheesan; Chehade N Karam; Marco L Alves; Ilona Bodi; Arnold Schwartz; Christian F Bulcao; Karen M D'Souza; Shahab A Akhter; Greg P Boivin; Dipak K Dube; Natalia Petrashevskaya; Andrew B Herr; Roger Hullin; Stephen B Liggett; Beata M Wolska; R John Solaro; David F Wieczorek
Journal: Circulation Date: 2010-01-11 Impact factor: 29.690

10. Role of tropomyosin in actin filament formation in embryonic salamander heart cells.

Authors: L F Lemanski
Journal: J Cell Biol Date: 1979-07 Impact factor: 10.539

12 in total

1. DNA microarray analysis reveals differential gene expression in the soleus muscle between male and female rats exposed to a high fat diet.

Authors: Tae Seok Oh; Jong Won Yun
Journal: Mol Biol Rep Date: 2012-02-04 Impact factor: 2.316

2. Identification of a novel TPM4 isoform transcript and comparison to the expression of other tropomyosin isoforms in bovine cardiac and skeletal muscles.

Authors: Syamalima Dube; Lynn Abbott; Samender Randhawa; Yingli Fan; Joseph W Sanger; Jean M Sanger; Bernard J Poiesz; Dipak K Dube
Journal: Int J Biochem Mol Biol Date: 2021-02-15

Expression of a novel tropomyosin isoform in axolotl heart and skeletal muscle.

Review 1. The molecular basis for tropomyosin isoform diversity.

Review 2. Functional properties of non-muscle tropomyosin isoforms.

3. Differential expression of a novel isoform of alpha-tropomyosin in cardiac and skeletal muscle of the Mexican axolotl (Ambystoma mexicanum).

4. Characterization of a TM-4 type tropomyosin that is essential for myofibrillogenesis and contractile activity in embryonic hearts of the Mexican axolotl.

5. Morphology of developing heart in cardiac lethal mutant Mexican axolotls, Ambystoma mexicanum.

6. Expression of a novel cardiac-specific tropomyosin isoform in humans.

7. Genetic and experimental studies on a mutant gene (c) determining absence of heart action in embryos of the Mexican axolotl (Ambystoma mexicanum).

8. Identification, characterization, and expression of a novel alpha-tropomyosin isoform in cardiac tissues in developing chicken.

9. Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform.

10. Role of tropomyosin in actin filament formation in embryonic salamander heart cells.

1. DNA microarray analysis reveals differential gene expression in the soleus muscle between male and female rats exposed to a high fat diet.

2. Identification of a novel TPM4 isoform transcript and comparison to the expression of other tropomyosin isoforms in bovine cardiac and skeletal muscles.

3. Expression of myotilin during chicken development.

4. Sarcomeric TPM3α in developing chicken.

5. Identification, characterization, and expression of sarcomeric tropomyosin isoforms in zebrafish.

6. Expression of Tropomyosin 1 Gene Isoforms in Human Breast Cancer Cell Lines.

Review 7. Expression of tropomyosin in relation to myofibrillogenesis in axolotl hearts.

8. Expression of tropomyosin 2 gene isoforms in human breast cancer cell lines.

9. Cloning, Sequencing, and the Expression of the Elusive Sarcomeric TPM4α Isoform in Humans.

10. Expression of TPM1κ, a Novel Sarcomeric Isoform of the TPM1 Gene, in Mouse Heart and Skeletal Muscle.