OBJECTIVE: To prospectively evaluate diffusion-weighted imaging (DWI) for early prediction of tumour response in patients with colorectal liver metastases following selective internal radiotherapy (SIRT). METHODS: We evaluated 41 metastases in 21 patients, age 62.9 ± 9.9 years. All patients underwent magnetic resonance imaging (MRI) including breath-hold echoplanar DWI sequences. Imaging was performed before therapy (baseline MRI), 2 days after SIRT (early MRI) as well as 6 weeks later (follow-up MRI). Tumour volume (TV) and intratumoural apparent diffusion coefficient (ADC) were measured independently by two radiologists at all time points. RESULTS: Metastases were categorised as responding lesions (RL; n = 33) or non-responding lesions (NRL; n = 8) according to changes in TV after 6 weeks. We found an inverse correlation of changes in TV and ADC at follow-up MRI with a Pearson's correlation coefficient of r = -0.66 (p < 0.0001). On early MRI, no significant changes in TV were found for either RL or NRL. Conversely, ADC decreased significantly in RL by 10.7 ± 8.4% (p < 0.0001). ADC increased in NRL by 9.6 ± 20.8%, which was not statistically significant (p = 0.40). CONCLUSION: DWI was capable of predicting therapy effects of SIRT in patients with colorectal hepatic metastases as early as 2 days following treatment.
OBJECTIVE: To prospectively evaluate diffusion-weighted imaging (DWI) for early prediction of tumour response in patients with colorectal liver metastases following selective internal radiotherapy (SIRT). METHODS: We evaluated 41 metastases in 21 patients, age 62.9 ± 9.9 years. All patients underwent magnetic resonance imaging (MRI) including breath-hold echoplanar DWI sequences. Imaging was performed before therapy (baseline MRI), 2 days after SIRT (early MRI) as well as 6 weeks later (follow-up MRI). Tumour volume (TV) and intratumoural apparent diffusion coefficient (ADC) were measured independently by two radiologists at all time points. RESULTS:Metastases were categorised as responding lesions (RL; n = 33) or non-responding lesions (NRL; n = 8) according to changes in TV after 6 weeks. We found an inverse correlation of changes in TV and ADC at follow-up MRI with a Pearson's correlation coefficient of r = -0.66 (p < 0.0001). On early MRI, no significant changes in TV were found for either RL or NRL. Conversely, ADC decreased significantly in RL by 10.7 ± 8.4% (p < 0.0001). ADC increased in NRL by 9.6 ± 20.8%, which was not statistically significant (p = 0.40). CONCLUSION: DWI was capable of predicting therapy effects of SIRT in patients with colorectal hepatic metastases as early as 2 days following treatment.
Authors: Dow-Mu Koh; Erica Scurr; David Collins; Baris Kanber; Andrew Norman; Martin O Leach; Janet E Husband Journal: AJR Am J Roentgenol Date: 2007-04 Impact factor: 3.959
Authors: Harriet C Thoeny; Frederik De Keyzer; Vincent Vandecaveye; Feng Chen; Xihe Sun; Hilde Bosmans; Robert Hermans; Eric K Verbeken; Chris Boesch; Guy Marchal; Willy Landuyt; Yicheng Ni Journal: Radiology Date: 2005-09-28 Impact factor: 11.105
Authors: B A Moffat; D E Hall; J Stojanovska; P J McConville; J B Moody; T L Chenevert; A Rehemtulla; B D Ross Journal: MAGMA Date: 2004-12-01 Impact factor: 2.310
Authors: Jie Deng; Frank H Miller; Thomas K Rhee; Kent T Sato; Mary F Mulcahy; Laura M Kulik; Riad Salem; Reed A Omary; Andrew C Larson Journal: J Vasc Interv Radiol Date: 2006-07 Impact factor: 3.464
Authors: Riad Salem; Kenneth G Thurston; Brian I Carr; James E Goin; Jean-Francois H Geschwind Journal: J Vasc Interv Radiol Date: 2002-09 Impact factor: 3.464
Authors: Tejas Parikh; Stephen J Drew; Vivian S Lee; Samson Wong; Elizabeth M Hecht; James S Babb; Bachir Taouli Journal: Radiology Date: 2008-01-25 Impact factor: 11.105
Authors: Thomas K Rhee; Neel K Naik; Jie Deng; Bassel Atassi; Mary F Mulcahy; Laura M Kulik; Robert K Ryu; Frank H Miller; Andrew C Larson; Riad Salem; Reed A Omary Journal: J Vasc Interv Radiol Date: 2008-06-25 Impact factor: 3.464
Authors: Andrew S Kennedy; David S Ball; Steven J Cohen; Michael Cohn; Douglas M Coldwell; Alain Drooz; Eduardo Ehrenwald; Samir Kanani; Charles W Nutting; Fred M Moeslein; Samuel G Putnam; Steven C Rose; Michael A Savin; Sabine Schirm; Navesh K Sharma; Eric A Wang Journal: J Gastrointest Oncol Date: 2015-12
Authors: Renu M Stephen; Abhinav K Jha; Denise J Roe; Theodore P Trouard; Jean-Philippe Galons; Matthew A Kupinski; Georgette Frey; Haiyan Cui; Scott Squire; Mark D Pagel; Jeffrey J Rodriguez; Robert J Gillies; Alison T Stopeck Journal: Magn Reson Imaging Date: 2015-08-15 Impact factor: 2.546