Literature DB >> 20563708

PI3Ks in lymphocyte signaling and development.

Klaus Okkenhaug1, David A Fruman.   

Abstract

Lymphocyte development and function are regulated by tyrosine kinase and G-protein coupled receptors. Each of these classes of receptors activates phosphoinositide 3-kinase (PI3K). In this chapter, we summarize current understanding of how PI3K contributes to key aspects of the adaptive immune system.

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Year:  2010        PMID： 20563708      PMCID： PMC4499567          DOI： 10.1007/82_2010_45

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  160 in total

1.  Frontline: The p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses.

Authors:  Kristen L Hess; Amber C Donahue; Kwan L Ng; Travis I Moore; Jean Oak; David A Fruman
Journal:  Eur J Immunol       Date:  2004-11       Impact factor: 5.532

2.  Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28.

Authors:  Vincenzo Mirenda; Sarah J Jarmin; Rachel David; Julian Dyson; Diane Scott; Yan Gu; Robert I Lechler; Klaus Okkenhaug; Federica M Marelli-Berg
Journal:  Blood       Date:  2007-04-01       Impact factor: 22.113

3.  Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation.

Authors:  Baher F Nashed; Tingting Zhang; Monther Al-Alwan; Ganesh Srinivasan; Andrew J Halayko; Klaus Okkenhaug; Bart Vanhaesebroeck; Kent T Hayglass; Aaron J Marshall
Journal:  Eur J Immunol       Date:  2007-02       Impact factor: 5.532

4.  Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.

Authors:  Jean S Oak; Jonathan A Deane; Michael G Kharas; Ji Luo; Thomas E Lane; Lewis C Cantley; David A Fruman
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-27       Impact factor: 11.205

5.  The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development.

Authors:  Heather J Hinton; Dario R Alessi; Doreen A Cantrell
Journal:  Nat Immunol       Date:  2004-04-11       Impact factor: 25.606

6.  Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing.

Authors:  Karin Reif; Klaus Okkenhaug; Takehiko Sasaki; Joseph M Penninger; Bart Vanhaesebroeck; Jason G Cyster
Journal:  J Immunol       Date:  2004-08-15       Impact factor: 5.422

7.  Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.

Authors:  Alexander Link; Tobias K Vogt; Stéphanie Favre; Mirjam R Britschgi; Hans Acha-Orbea; Boris Hinz; Jason G Cyster; Sanjiv A Luther
Journal:  Nat Immunol       Date:  2007-09-23       Impact factor: 25.606

8.  Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.

Authors:  Mathieu Gigoux; Jijun Shang; Youngshil Pak; Minghong Xu; Jongseon Choe; Tak W Mak; Woong-Kyung Suh
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-13       Impact factor: 11.205

9.  Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase.

Authors:  Amanda L Martin; Matthew D Schwartz; Stephen C Jameson; Yoji Shimizu
Journal:  J Immunol       Date:  2008-02-15       Impact factor: 5.422

10.  Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells.

Authors:  Daniel T Patton; Oliver A Garden; Wayne P Pearce; Louise E Clough; Clare R Monk; Eva Leung; Wendy C Rowan; Sara Sancho; Lucy S K Walker; Bart Vanhaesebroeck; Klaus Okkenhaug
Journal:  J Immunol       Date:  2006-11-15       Impact factor: 5.422
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  37 in total

1.  Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells.

Authors:  Ildiko Györy; Sören Boller; Robert Nechanitzky; Elizabeth Mandel; Sebastian Pott; Edison Liu; Rudolf Grosschedl
Journal:  Genes Dev       Date:  2012-03-19       Impact factor: 11.361

2.  Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets.

Authors:  Qing Xiong; Nicola Ancona; Elizabeth R Hauser; Sayan Mukherjee; Terrence S Furey
Journal:  Genome Res       Date:  2011-09-22       Impact factor: 9.043

Review 3.  Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes.

Authors:  Prasenjit Manna; Sushil K Jain
Journal:  Cell Physiol Biochem       Date:  2015-02-11

Review 4.  Signaling in lymphocyte activation.

Authors:  Doreen Cantrell
Journal:  Cold Spring Harb Perspect Biol       Date:  2015-06-01       Impact factor: 10.005

5.  Study of Signal Transduction Pathways by Phospho-Protein Evaluation.

Authors:  Manuela Capone; Alessio Mazzoni; Laura Maggi
Journal:  Methods Mol Biol       Date:  2021

Review 6.  PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances.

Authors:  Lomon So; David A Fruman
Journal:  Biochem J       Date:  2012-03-15       Impact factor: 3.857

7.  Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function.

Authors:  Lomon So; Sung Su Yea; Jean S Oak; Mengrou Lu; Arun Manmadhan; Qiao Han Ke; Matthew R Janes; Linda V Kessler; Jeff M Kucharski; Lian-Sheng Li; Michael B Martin; Pingda Ren; Katti A Jessen; Yi Liu; Christian Rommel; David A Fruman
Journal:  J Biol Chem       Date:  2012-12-28       Impact factor: 5.157

Review 8.  PI3K and cancer: lessons, challenges and opportunities.

Authors:  David A Fruman; Christian Rommel
Journal:  Nat Rev Drug Discov       Date:  2014-02       Impact factor: 84.694

9.  Too much of a good thing: immunodeficiency due to hyperactive PI3K signaling.

Authors:  Craig M Walsh; David A Fruman
Journal:  J Clin Invest       Date:  2014-08-18       Impact factor: 14.808

10.  A PI3K p110α-selective inhibitor enhances the efficacy of anti-HER2/neu antibody therapy against breast cancer in mice.

Authors:  Jae-Hyeog Choi; Ki Hyang Kim; Kug-Hwan Roh; Hana Jung; Anbok Lee; Ji-Young Lee; Joo Yeon Song; Seung Jae Park; Ilhwan Kim; Won-Sik Lee; Su-Kil Seo; Il-Whan Choi; Yang-Xin Fu; Sung Su Yea; SaeGwang Park
Journal:  Oncoimmunology       Date:  2018-01-16       Impact factor: 8.110
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