Literature DB >> 20563660

Furostanol glycosides from the rhizomes of Helleborus orientalis.

Yoshihiro Mimaki1, Yukiko Matsuo, Kazuki Watanabe, Hiroshi Sakagami.   

Abstract

Eight new furostanol glycosides (1-8), together with two known ones (9 and 10), have been isolated from a glycoside-enriched fraction prepared from the rhizomes of Helleborus orientalis (Ranunculaceae). The structures of 1-8 were determined on the basis of extensive spectroscopic analysis, including 2D NMR, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity against HSC-2 cells.

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Year:  2010        PMID： 20563660     DOI： 10.1007/s11418-010-0432-7

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  3 in total

1.  [Botanical and phytochemical investigations of species of the genus Helleborus growing in Europe and Asian Minor. II. Comparative phytochemical investigations of the cardio active glycosides and saponins (author's transl)].

Authors:  W Wissner; H Kating
Journal:  Planta Med       Date:  1974-11       Impact factor: 3.352

2.  New steroidal constituents of the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells.

Authors:  Y Mimaki; M Kuroda; A Kameyama; A Yokosuka; Y Sashida
Journal:  Chem Pharm Bull (Tokyo)       Date:  1998-02       Impact factor: 1.645

3.  Bufadienolide and spirostanol glycosides from the rhizomes of helleborusorientalis.

Authors:  Kazuki Watanabe; Yoshihiro Mimaki; Hiroshi Sakagami; Yutaka Sashida
Journal:  J Nat Prod       Date:  2003-02       Impact factor: 4.050
  3 in total

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