Literature DB >> 20562818

Immune response of BALB/c mice against an experimental vaccine of Alum precipitated autoclaved Leishmania major (Alum-ALM) mixed with BCG or Mycobacterium vaccae.

M Nateghi Rostami1, H Keshavarz, A Khamesipour.   

Abstract

Immune response in BALB/c mice immunized 3 times with different doses (50 μg or 200 μg of protein) of Alum precipitated autoclaved Leishmania major (Alum-ALM) mixed with either BCG (1x10(7); CFU) or different doses of killed Mycobacterium vaccae (1x10(6), 1x10(7)) was assessed. Mice immunized with low dose of Alum-ALM mixed with either BCG or low M. vaccae showed a significantly higher IFN-gamma production and a lower IL-4 level and a significantly lower parasite burden compared to the control PBS injected group. It seems that immunization with a low dose of Alum-ALM mixed with an adjuvant induces a Th1 type of immune response in susceptible BALB/c mice.

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Year:  2010        PMID： 20562818

Source DB:  PubMed          Journal:  Trop Biomed        ISSN： 0127-5720            Impact factor:   0.623


  5 in total

1.  Evaluation of the immunogenicity and protective efficacy of killed Leishmania donovani antigen along with different adjuvants against experimental visceral leishmaniasis.

Authors:  Ankita Thakur; Harpreet Kaur; Sukhbir Kaur
Journal:  Med Microbiol Immunol       Date:  2014-11-29       Impact factor: 3.402

2.  CCR7+ central and CCR7- effector memory CD4+ T cells in human cutaneous leishmaniasis.

Authors:  Hossein Keshavarz Valian; Mahmoud Nateghi Rostami; Minoo Tasbihi; Akram Miramin Mohammadi; Seyed Ebrahim Eskandari; Abdolfattah Sarrafnejad; Ali Khamesipour
Journal:  J Clin Immunol       Date:  2012-09-19       Impact factor: 8.317

3.  CD8+ T cells as a source of IFN-γ production in human cutaneous leishmaniasis.

Authors:  Mahmoud Nateghi Rostami; Hossein Keshavarz; Rosita Edalat; Abdolfattah Sarrafnejad; Tahereh Shahrestani; Fereidoun Mahboudi; Ali Khamesipour
Journal:  PLoS Negl Trop Dis       Date:  2010-10-12

4.  Leishmania donovani whole cell antigen delivered with adjuvants protects against visceral leishmaniasis in vervet monkeys (Chlorocebus aethiops).

Authors:  Joshua Muli Mutiso; John Chege Macharia; Evans Taracha; Michael Muita Gicheru
Journal:  J Biomed Res       Date:  2012-01

5.  IL-4 contributes to failure, and colludes with IL-10 to exacerbate Leishmania donovani infection following administration of a subcutaneous leishmanial antigen vaccine.

Authors:  Sudipta Bhowmick; Rajesh Ravindran; Nahid Ali
Journal:  BMC Microbiol       Date:  2014-01-15       Impact factor: 3.605
  5 in total

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