BACKGROUND: Living kidney transplant donors generally have a favorable renal functional outcome postuninephrectomy, but concern remains that a reduced glomerular filtration rate (GFR) postuninephrectomy might have harmful effects. This study examines the short-term (3 months) effect of donor nephrectomy on GFR and the occurrence of stage 3 chronic kidney disease (CKD) postuninephrectomy. METHODS: The prevalence of stage 3 CKD (Kidney Disease Quality Outcome Initiative [GFR<60 mL/min/1.73 m]) was examined in 196 living donors by comparing preuninephrectomy and 3-month postuninephrectomy values of GFR using I-iothalamate GFR (iGFR), modification of diet in renal disease estimated GFR (eGFR), Cockcroft-Gault estimated creatinine clearance, and endogenous 24-hr creatinine clearance. The accuracy of GFR estimations for predicting iGFR was also studied. RESULTS: The mean GFR before and after donation were iGFR, 105+/-18 and 68+/-13 mL/min/1.73 m; eGFR, 98+/-19 and 63+/-12 mL/min/1.73 m; Cockcroft-Gault estimated creatinine clearance, 125+/-33 and 85+/-22 mL/min/1.73 m, and endogenous 24-hr creatinine clearance, 133+/-38 and 86+/-24 mL/min/1.73 m, respectively. Stage 3 CKD was found postuninephrectomy in 53 donors (27%) by iGFR and in 73 donors (38%) by eGFR. The prevalence of stage 3 CKD was greater with older age. GFR estimation equations did not accurately predict iGFR, particularly postuninephrectomy. CONCLUSIONS: Stage 3 CKD is commonly observed after living kidney donation, particularly in older donors. The long-term impact of stage 3 CKD postuninephrectomy is poorly understood and may not have the same implications as stage 3 CKD in other conditions. eGFR is a poor predictor of true GFR in kidney donors.
BACKGROUND: Living kidney transplant donors generally have a favorable renal functional outcome postuninephrectomy, but concern remains that a reduced glomerular filtration rate (GFR) postuninephrectomy might have harmful effects. This study examines the short-term (3 months) effect of donor nephrectomy on GFR and the occurrence of stage 3 chronic kidney disease (CKD) postuninephrectomy. METHODS: The prevalence of stage 3 CKD (Kidney Disease Quality Outcome Initiative [GFR<60 mL/min/1.73 m]) was examined in 196 living donors by comparing preuninephrectomy and 3-month postuninephrectomy values of GFR using I-iothalamate GFR (iGFR), modification of diet in renal disease estimated GFR (eGFR), Cockcroft-Gault estimated creatinine clearance, and endogenous 24-hr creatinine clearance. The accuracy of GFR estimations for predicting iGFR was also studied. RESULTS: The mean GFR before and after donation were iGFR, 105+/-18 and 68+/-13 mL/min/1.73 m; eGFR, 98+/-19 and 63+/-12 mL/min/1.73 m; Cockcroft-Gault estimated creatinine clearance, 125+/-33 and 85+/-22 mL/min/1.73 m, and endogenous 24-hr creatinine clearance, 133+/-38 and 86+/-24 mL/min/1.73 m, respectively. Stage 3 CKD was found postuninephrectomy in 53 donors (27%) by iGFR and in 73 donors (38%) by eGFR. The prevalence of stage 3 CKD was greater with older age. GFR estimation equations did not accurately predict iGFR, particularly postuninephrectomy. CONCLUSIONS: Stage 3 CKD is commonly observed after living kidney donation, particularly in older donors. The long-term impact of stage 3 CKD postuninephrectomy is poorly understood and may not have the same implications as stage 3 CKD in other conditions. eGFR is a poor predictor of true GFR in kidney donors.
Authors: Jonathan L Silberstein; Nicholas E Power; Caroline Savage; Tatum V Tarin; Ricardo L Favaretto; Daniel Su; Matthew G Kaag; Harry W Herr; Guido Dalbagni Journal: J Urol Date: 2011-12-15 Impact factor: 7.450
Authors: Courtenay M Holscher; Tanveen Ishaque; Jacqueline M Garonzik Wang; Christine E Haugen; Sandra R DiBrito; Kyle R Jackson; Abimereki D Muzaale; Allan B Massie; Fawaz Al Ammary; Shane E Ottman; Macey L Henderson; Dorry L Segev Journal: Am J Transplant Date: 2018-08-31 Impact factor: 8.086
Authors: Bertram L Kasiske; Rajiv Kumar; Paul L Kimmel; Todd E Pesavento; Roberto S Kalil; Edward S Kraus; Hamid Rabb; Andrew M Posselt; Teresa L Anderson-Haag; Michael W Steffes; Ajay K Israni; Jon J Snyder; Ravinder J Singh; Matthew R Weir Journal: Kidney Int Date: 2016-06-28 Impact factor: 10.612
Authors: William E Moody; Charles J Ferro; Nicola C Edwards; Colin D Chue; Erica Lai Sze Lin; Robin J Taylor; Paul Cockwell; Richard P Steeds; Jonathan N Townend Journal: Hypertension Date: 2016-02 Impact factor: 10.190