PURPOSE: In patients with heart failure, reduced cardiac ejection fraction has been associated with impaired cognition. Improving cardiac function may have beneficial effects on cognition; however, no controlled intervention studies have examined this possibility. Cardiac resynchronization therapy (CRT) is one intervention that has been shown to increase cardiac function. The goals of the current study were to (1) evaluate neuropsychological performance before and 3 months after crt and (2) examine follow-up neuropsychological performance of patients classified on the basis of extent of improved left ventricular ejection fraction (LVEF). METHODS: Twenty-seven patients with moderate to severe heart failure completed a neuropsychological assessment, 6-minute walk test, and transthoracic echocardiography before and 3 months after CRT. Patients were classified on the basis of improvement in LVEF. Results of a multivariate analysis of variance revealed a significant effect of improvement in LVEF on change in cognition (Wilks Λ, P = .031). RESULTS: Patients with improved LVEF demonstrated significant increases on measures of executive functioning (F = 8.57, P = .007) and visuospatial function (F = 7.52, P = .011) and less decline on global cognition (F = 5.73, P = .024) than those without LVEF improvement. CONCLUSIONS: Findings provide preliminary evidence that improved LVEF in response to CRT is associated with enhanced cognitive outcomes within 3 months of CRT. Patients with improved LVEF showed better outcomes on measures of executive functioning, global cognition, and visuospatial functioning. Future, controlled, large-scale trials will be necessary to determine whether there is an underlying causal relationship linking increase in LVEF and cognition.
PURPOSE: In patients with heart failure, reduced cardiac ejection fraction has been associated with impaired cognition. Improving cardiac function may have beneficial effects on cognition; however, no controlled intervention studies have examined this possibility. Cardiac resynchronization therapy (CRT) is one intervention that has been shown to increase cardiac function. The goals of the current study were to (1) evaluate neuropsychological performance before and 3 months after crt and (2) examine follow-up neuropsychological performance of patients classified on the basis of extent of improved left ventricular ejection fraction (LVEF). METHODS: Twenty-seven patients with moderate to severe heart failure completed a neuropsychological assessment, 6-minute walk test, and transthoracic echocardiography before and 3 months after CRT. Patients were classified on the basis of improvement in LVEF. Results of a multivariate analysis of variance revealed a significant effect of improvement in LVEF on change in cognition (Wilks Λ, P = .031). RESULTS:Patients with improved LVEF demonstrated significant increases on measures of executive functioning (F = 8.57, P = .007) and visuospatial function (F = 7.52, P = .011) and less decline on global cognition (F = 5.73, P = .024) than those without LVEF improvement. CONCLUSIONS: Findings provide preliminary evidence that improved LVEF in response to CRT is associated with enhanced cognitive outcomes within 3 months of CRT. Patients with improved LVEF showed better outcomes on measures of executive functioning, global cognition, and visuospatial functioning. Future, controlled, large-scale trials will be necessary to determine whether there is an underlying causal relationship linking increase in LVEF and cognition.
Authors: Angela L Jefferson; Christopher M Holland; David F Tate; Istvan Csapo; Athena Poppas; Ronald A Cohen; Charles R G Guttmann Journal: Neurobiol Aging Date: 2009-03-09 Impact factor: 4.673
Authors: David J Bradley; Elizabeth A Bradley; Kenneth L Baughman; Ronald D Berger; Hugh Calkins; Steven N Goodman; David A Kass; Neil R Powe Journal: JAMA Date: 2003-02-12 Impact factor: 56.272
Authors: W F Kerwin; E H Botvinick; J W O'Connell; S H Merrick; T DeMarco; K Chatterjee; K Scheibly; L A Saxon Journal: J Am Coll Cardiol Date: 2000-04 Impact factor: 24.094
Authors: Giuseppe Zuccalà; Claudio Pedone; Matteo Cesari; Graziano Onder; Marco Pahor; Emanuele Marzetti; Maria R Lo Monaco; Alberto Cocchi; Pierugo Carbonin; Roberto Bernabei Journal: Am J Med Date: 2003-08-01 Impact factor: 4.965
Authors: Debra K Moser; Cynthia Arslanian-Engoren; Martha J Biddle; Misook Lee Chung; Rebecca L Dekker; Muna H Hammash; Gia Mudd-Martin; Abdullah S Alhurani; Terry A Lennie Journal: Curr Cardiol Rep Date: 2016-12 Impact factor: 2.931
Authors: Michael L Alosco; Sarah Garcia; Mary Beth Spitznagel; Manfred van Dulmen; Ronald Cohen; Lawrence H Sweet; Richard Josephson; Joel Hughes; Jim Rosneck; John Gunstad Journal: Neuropsychol Dev Cogn B Aging Neuropsychol Cogn Date: 2013-08-01
Authors: Diewertje I Bink; Katja Ritz; Eleonora Aronica; Louise van der Weerd; Mat J A P Daemen Journal: J Cereb Blood Flow Metab Date: 2013-08-21 Impact factor: 6.200
Authors: Michael L Alosco; John Gunstad; Beth A Jerskey; Uraina S Clark; Jason J Hassenstab; Xiaomeng Xu; Athena Poppas; Ronald A Cohen; Lawrence H Sweet Journal: Int J Neurosci Date: 2013-03-14 Impact factor: 2.292